The Effect of Alcoholic Extract of Physalis alkekengi on Serum Concentration of Thyroid Hormones in Rats

Shahnaz Shekar-Foroosh; Saeed Changizi-Ashtiyani; Bijan Akbarpour; Mohammad Attari; Ali Zarei; Majid Ramazani

Zahedan Journal of Research in Medical Sciences

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The Effect of Alcoholic Extract of Physalis alkekengi on Serum Concentration of Thyroid Hormones in Rats

Author(s):

Shahnaz Shekar-Foroosh¹,

Saeed Changizi-Ashtiyani²,

Bijan Akbarpour³,

Mohammad Attari¹,

Ali Zarei^4,*,

Majid Ramazani⁵

1Department of Physiology, Azad University of Arsanjan, Arsanjan, Iran

2Department of Physiology, Arak University of Medical Sciences, Arak, Iran

3Department of Physiology, Azad University of Kazeron, ,Kazeron, Iran

4Department of Physiology, Payame Noor University of Bavanat, Fars, Iran

5Department of Internal Medicine, Baghiatallah University of Medical Sciences, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 5; e93442

Published online:Feb 13, 2012

Article type:Research Article

Received:Apr 23, 2011

Accepted:May 11, 2011

How to Cite:Shahnaz Shekar-ForooshSaeed Changizi-AshtiyaniBijan AkbarpourMohammad AttariAli ZareiMajid Ramazaniet al.The Effect of Alcoholic Extract of Physalis alkekengi on Serum Concentration of Thyroid Hormones in Rats.Zahedan J Res Med Sci.14(5):e93442.

Abstract

Background: There are different factors which are effective on maintaining homeostasis, especially by pituitary-thyroid axis hormones. The objective of this study was to examine the effect of Physalis alkekengi plant extract belonging to Solanaceae family on the concentration of the pituitary-thyroid axis hormones.
Materials and Methods: This study was conducted on five groups (n=10) of male Wistar rats (with mean weight 210±5g). The control group did not receive any substances, while the reference group received 0.2 ml normal saline daily and the experimental groups received maximum (0.4 g/kg), moderate (0.2 g/kg), and minimum (0.1 g/kg) intraperitoneal (IP) doses of the alcoholic extract for 14 days. At the end of this period, blood samples were drawn and the results were analyzed by SPSS-11.5 software.
Results: The results of statistical analysis showed significant increases in plasma concentrations of thyroxin (T4) and triiodothyronine (T3) in the maximum dose group (p<0.05) with no significant changes in plasma concentrations of thyroid-stimulating hormone (TSH).
Conclusion: Increases in T3 and T4 levels with no changes in TSH concentration indicate hyperthyroidism euthyroidism in which the levels of thyroid hormones increase while the amount of TSH remains constant. These changes could be due to plasma proteins increase including albumin, which are probably induced by physaline and alkaloids existing in Physalis alkekengi. So, these drug doses do not seem to bring about pathological changes in the pituitary-thyroid axis.

Keywords

Physalis alkekengi

Rat

Thyroid Stimulating Hormone

Pituitary Gland

Hyperthyroidism

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