The Relationship between Interleukin-6 -174 G/C Gene Polymorphism and Chronic Periodontitis

1Department of Histology, Research Center for Infectious Diseases and Tropical Medicine, Boo-Ali Hospital, Zahedan University of Medical Sciences, Zahedan, Iran

2Department of Clinical Biochemistry, Cellular and Molecular Research Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

3Department of Periodontology, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 3; e93544

Published online:Mar 18, 2012

Article type:Research Article

Received:Dec 20, 2011

Accepted:Jan 12, 2012

How to Cite:Tayebeh SanchooliHamidreza Mahmoudzadeh-SaghebHamidreza Mahmoudzadeh-SaghebMohammad HashemiMohammad Ayub Rigi-LadizThe Relationship between Interleukin-6 -174 G/C Gene Polymorphism and Chronic Periodontitis.Zahedan J Res Med Sci.14(3):e93544.

Abstract

Background: Chronic periodontitis is an inflammatory disease that causes rapid destruction of the tissues supporting the teeth. Genetic and environmental factors are involved in its occurrence. It has been suggested that IL-6 promoter gene polymorphism could affect the severity of chronic periodontitis. This study has examined the relationship between IL-6 (-174G/C) gene polymorphism and chronic periodontitis.
Materials and Methods: In this case-control study, 100 patients with chronic periodontitis and 100 healthy individuals referring to the clinic of Zahedan Dental School were evaluated. Two ml of peripheral blood was taken from these people. After DNA extraction through salting out method, IL-6 gene polymorphism was determined through T-ARMS-PCR technique using specific primers. The data were analyzed by chi-square test and p<0/05was considered significant.
Results: The frequency of genotypes CC, GC, GG was respectively 61%, 35% and 4% in patients and respectively 67%, 31% and 2% in the control group. The frequency of G and C alleles was respectively 78.5% and 21.5% in the patient group, and respectively 82.5% and 17.5% in control group. No statistically significant difference was observed between the two groups in frequency of genotypes and alleles.
Conclusion: This study showed no correlation between IL-6-174 G/C gene polymorphism and chronic periodontitis.

Keywords

Chronic Periodontitis

Polymorphism

IL-6

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