The Effect of Time-Varying Low Intensity ELF Magnetic Field on Growth Rate of Invasive Ductal Carcinoma on Balb/C Mice

akram mahna; Mohammad Firoozabadi; Zeinab Shankayi

Zahedan Journal of Research in Medical Sciences

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The Effect of Time-Varying Low Intensity ELF Magnetic Field on Growth Rate of Invasive Ductal Carcinoma on Balb/C Mice

Author(s):

akram mahna¹,

Mohammad Firoozabadi^2,*,

Zeinab Shankayi¹

1Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

2Department of Medical Engineering, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 3; e93548

Published online:Jul 27, 2011

Article type:Research Article

Received:Mar 13, 2011

Accepted:Jul 14, 2011

How to Cite:akram mahnaMohammad FiroozabadiZeinab ShankayiThe Effect of Time-Varying Low Intensity ELF Magnetic Field on Growth Rate of Invasive Ductal Carcinoma on Balb/C Mice.Zahedan J Res Med Sci.14(3):e93548.

Abstract

Background: Extremely low frequency (ELF) magnetic fields have been considered by researchers as a noninvasive treatment approach. Citing documented biological effects of ELF magnetic fields in recent studies, we investigate the effect of low intensity ELF magnetic field on the treatment of invasive ductal carcinoma tumor.
Materials and Methods : Female Balb/c mice were transplanted with invasive ductal carcinoma tumors. Extremely low frequency magnetic field (100 pulse per second EMF (150 μT)) with static magnetic field (400 μT) as a background exposure was applied as a combined protocol for the treatment of the tumors. Other treatment groups in this study were control group (with no treatment), static magnetic field exposure group at 400 μT (sham group), chemotherapy by bleomycin intratumoral injection group and finally a group with the combined protocol after intratumoral injection of bleomycin. All groups were treated in the magnetic field for 10 minutes per day for 12 days.
Results: The results of this study showed that static and ELF magnetic field had no significant effect on the invasive ductal carcinoma tumor growth process. But static magnetic field indicated a significant decrease in tumor growth in the last days of the follow up. Also combined protocol significantly increased toxic effect of bleomycin as a chemotherapy agent.
Conclusion: Low intensity static magnetic field can be considered as an antitumor factor. Also combined magnetic fields can be used for increasing the effects of chemotherapy in cancerous patients.

Keywords

Magnetic field therapy

Bleomycin

Mammary Tumor Virus

Mouse

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