Treatment of Colon Carcinoma Tumors in Balb/cMicethrough the Electrolysis Method: The Effect of Dose Distribution

mahdi shirinshandiz; Amene Sazgarnia; Mohamad H. Bahreyni-Toosi; Shahram Bayani-Roudi; Javad Keikhai-Farzaneh

Zahedan Journal of Research in Medical Sciences

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Treatment of Colon Carcinoma Tumors in Balb/cMicethrough the Electrolysis Method: The Effect of Dose Distribution

Author(s):

mahdi shirinshandiz^1,*,

Amene Sazgarnia²,

Mohamad H. Bahreyni-Toosi²,

Shahram Bayani-Roudi¹,

Javad Keikhai-Farzaneh¹

1Department of Medical Physics, Zahedan University of Medical Sciences, Zahedan, Iran

2Department of Medical Physics, Research Center of Medical Physics, Mashhad University of Medical Sciences, Mashhad, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 14, issue 3; e93564

Published online:Jun 20, 2011

Article type:Research Article

Received:Nov 24, 2009

Accepted:Jul 26, 2010

How to Cite:mahdi shirinshandizAmene SazgarniaMohamad H. Bahreyni-ToosiShahram Bayani-RoudiJavad Keikhai-FarzanehTreatment of Colon Carcinoma Tumors in Balb/cMicethrough the Electrolysis Method: The Effect of Dose Distribution.Zahedan J Res Med Sci.14(3):e93564.

Abstract

Background: Electrolysis therapy is a new effective physical method for treating localized cancers, in which the effects of direct electric current, including drastic changes in pH, produced toxins and effects of electric field are used to destroy tumors. This study discusses the above method and the effect of dose distribution in treatment efficiency in tumor colon carcinoma model in Balb/c mice.
Materials and Methods: In this experimental study, first colon carcinoma tumor was induced in 60 Balb/c mice. When tumor volume reached 340± 30 mm3, the animals were randomly divided into four groups. A current supply was used in group 3 and 3 current supplies were used in group 4 to apply dose of 20 coulombs per cubic centimeter (C/mm3) through six electrodes located at base and top of the tumor. In addition to reviewing the pathology to confirm the tumor and its treatment effects, the daily measurement of tumor size and mortality of animals was also recorded.
Results: While in control groups the tumors grew quickly and without even a regression and survival fraction got zero within 50 days after the electrolysis, in groups 3 and 4, complete destruction was recorded respectively 40 (8/20) and 60 (12/20) percent, which represented a significant increase in the complete destruction in both treatment group 3 (p = 0/029) and 4 (p = 0/002) compared to the control groups. In addition, survival fraction increased in treatment groups so that survival increase in group 4 was quite significant compared to the control groups (p =0/02).
Conclusion: The evidences suggest the anti-tumor effects and a high potential for electrolysis therapy in treatment and destruction of tumors and control of their growth, the efficiency of which can improve through solutions such as use of more current supplies.

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