Abstract
Background: Electrolysis therapy is a new effective physical method for treating localized cancers, in which the effects of direct electric current, including drastic changes in pH, produced toxins and effects of electric field are used to destroy tumors. This study discusses the above method and the effect of dose distribution in treatment efficiency in tumor colon carcinoma model in Balb/c mice.
Materials and Methods: In this experimental study, first colon carcinoma tumor was induced in 60 Balb/c mice. When tumor volume reached 340± 30 mm3, the animals were randomly divided into four groups. A current supply was used in group 3 and 3 current supplies were used in group 4 to apply dose of 20 coulombs per cubic centimeter (C/mm3) through six electrodes located at base and top of the tumor. In addition to reviewing the pathology to confirm the tumor and its treatment effects, the daily measurement of tumor size and mortality of animals was also recorded.
Results: While in control groups the tumors grew quickly and without even a regression and survival fraction got zero within 50 days after the electrolysis, in groups 3 and 4, complete destruction was recorded respectively 40 (8/20) and 60 (12/20) percent, which represented a significant increase in the complete destruction in both treatment group 3 (p = 0/029) and 4 (p = 0/002) compared to the control groups. In addition, survival fraction increased in treatment groups so that survival increase in group 4 was quite significant compared to the control groups (p =0/02).
Conclusion: The evidences suggest the anti-tumor effects and a high potential for electrolysis therapy in treatment and destruction of tumors and control of their growth, the efficiency of which can improve through solutions such as use of more current supplies.
Materials and Methods: In this experimental study, first colon carcinoma tumor was induced in 60 Balb/c mice. When tumor volume reached 340± 30 mm3, the animals were randomly divided into four groups. A current supply was used in group 3 and 3 current supplies were used in group 4 to apply dose of 20 coulombs per cubic centimeter (C/mm3) through six electrodes located at base and top of the tumor. In addition to reviewing the pathology to confirm the tumor and its treatment effects, the daily measurement of tumor size and mortality of animals was also recorded.
Results: While in control groups the tumors grew quickly and without even a regression and survival fraction got zero within 50 days after the electrolysis, in groups 3 and 4, complete destruction was recorded respectively 40 (8/20) and 60 (12/20) percent, which represented a significant increase in the complete destruction in both treatment group 3 (p = 0/029) and 4 (p = 0/002) compared to the control groups. In addition, survival fraction increased in treatment groups so that survival increase in group 4 was quite significant compared to the control groups (p =0/02).
Conclusion: The evidences suggest the anti-tumor effects and a high potential for electrolysis therapy in treatment and destruction of tumors and control of their growth, the efficiency of which can improve through solutions such as use of more current supplies.
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© 2012, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.