Rapid diagnostic tests for tuberculosis

Roya Alavi-Naini; Batool Sharifi-Mood; Maliheh  Metanat; S. Ahmad Hashemi

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

Current Issue All Issues In Press Articles Accepted Manuscripts Search

Journal Information Boards and Committees Indexing and Listing Sources Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support Reviewer and AE Registration Form

APC

Authors Guide Submit Manuscript

Rapid diagnostic tests for tuberculosis

Author(s):

Roya Alavi-Naini¹,

Batool Sharifi-Mood ²,

Maliheh Metanat^1,*,

S. Ahmad Hashemi³

1Associate Professor of Infecious Diseases, Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

2Professor of Infecious Diseases, Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

3Physician, Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 13, issue 7; e93811

Published online:Oct 26, 2011

Article type:Review Article

Received:Feb 08, 2011

Accepted:May 11, 2011

How to Cite:Roya Alavi-NainiBatool Sharifi-Mood Maliheh MetanatS. Ahmad HashemiRapid diagnostic tests for tuberculosis.Zahedan J Res Med Sci.13(7):e93811.

Abstract

Background: Tuberculosis (TB) is still an important heath issue in developing countries. According to low sensitivity of sputum smear and prolonged declaration of culture results, we reviewed rapid diagnostic tests for tuberculosis in this article.

Materials and Method: Electronic databases (PubMed and Embase) were searched from 1990 to 2010 for rapid diagnostic tests. Key words like tuberculosis, Mycobacterium tuberculosis and rapid tests were used. In this review article we discussed about the accuracy of rapid diagnostic tests for the diagnosis of tuberculosis.

Results: Serologic and enzyme tests such as adenosine deaminase and cytokines revealed different results. Nucleic acid amplification tests (NAATS) provided higher accuracy for sputum positive pulmonary TB. The specificity of NAATS was high in pulmonary and extra pulmonary tuberculosis. Automated liquid culture (radiometric and non-radiometric) had higher speed and accuracy in comparison to conventional solid media culture.

Conclusion: Despite many efforts for rapid detection of TB, sputum microscopic smears and cultures remain the principal diagnostic tests for TB patients. Sophosticated equipments and experienced personels are usually required for performing some of the newer rapid diagnostic tests. Investigation for novel rapid diagnostic tests are ongoing.

Keywords

Tuberculosis

mycobacterium tuberculosis

rapid diagnostic tests

Fulltext

The full text of this article is available on the PDF file.

References

1.
The References of this article are available on the PDF file.

comments