Association between methylene tetrahydrofolate reductase gene C677T polymorphism with preeclampsia in south-east of Iran

Mohsen Saravani; Saeedeh  Salimi; Minoo Yaghmaee; mojgan mokhtari; mehdi jafari

Zahedan Journal of Research in Medical Sciences

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Association between methylene tetrahydrofolate reductase gene C677T polymorphism with preeclampsia in south-east of Iran

Author(s):

Mohsen Saravani¹,

Saeedeh Salimi^2,*,

Minoo Yaghmaee³,

mojgan mokhtari⁴,

mehdi jafari⁵

1MSc student of clinical biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

2Assistant professor of clinical biochemistry, Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.

3Associated professor of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

4Associated professor of Obstetrics and Gynecology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran.

5MSc student of clinical biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

Zahedan Journal of Research in Medical Sciences:Vol. 13, issue 7; e93821

Published online:Sep 20, 2011

Article type:Research Article

Received:Jun 04, 2011

Accepted:Jun 23, 2011

How to Cite:Mohsen SaravaniSaeedeh SalimiMinoo Yaghmaeemojgan mokhtarimehdi jafariAssociation between methylene tetrahydrofolate reductase gene C677T polymorphism with preeclampsia in south-east of Iran.Zahedan J Res Med Sci.13(7):e93821.

Abstract

Background: Preeclampsia (PE) is a serious problem of pregnancy and its etiology is still unknown. There are some evidence that vascular complications play an important role in development of PE. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism and the C677T polymorphism of the MTHFR gene is associated with decreased MTHFR activity. The aim of this study was to evaluate the relationship between MTHFR gene C677T polymorphism with PE development in south-east of Iran.

Materials and method: This study was performed in 106 preeclamptic pregnant women and 107 control individuals. The C677T polymorphism of the MTHFR gene was determined by PCR-RFLP method.

Results: The CC, CT and TT genotypes frequency of C677T polymorphism of MTHFR gene were 77, 22 and 1 percent in preeclamptic women and 73, 19.5 and 7.5 percent in control group. They were not significantly different (p=0.06). However, the frequency of TT genotype was significantly higher in control group (OR=8.5 95% CI 1.1-71 p=.018). There was not any significant difference in T allele distribution between preeclamptic women (12%) and control group (17%).

Conclusion: Our results showed that there was not any correlation between the C677T polymorphism and PE but the TT genotype of C677T polymorphism seems to be a protective factor for preeclampsia.

Keywords

Preeclampsia

methylenetetrahydrofolate reductase

polymorphism

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