Antibacterial activity of methanol extract and essential oil of Achillea wilhelmsii against pathogenic bacteria

Maryam Mohammadi Sichani; Leila Amjad; Marzyeh Mohammadi-Kamalabadi

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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Antibacterial activity of methanol extract and essential oil of Achillea wilhelmsii against pathogenic bacteria

Author(s):

Maryam Mohammadi Sichani^1,*,

Leila Amjad²,

Marzyeh Mohammadi-Kamalabadi³

1Instructor of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.

2Assistant Professor of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran

3MSc of Microbiology, Young Researchers Club, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 13, issue 3; e94008

Published online:Apr 27, 2011

Article type:Review Article

Received:Jul 14, 2010

Accepted:Aug 24, 2010

How to Cite:Maryam Mohammadi SichaniLeila AmjadMarzyeh Mohammadi-KamalabadiAntibacterial activity of methanol extract and essential oil of Achillea wilhelmsii against pathogenic bacteria.Zahedan J Res Med Sci.13(3):e94008.

Abstract

Background: Increased bacterial resistance to antibacterial agents is one of the most common problems in medicine. Herbal remedies used in the traditional medicine provide an interesting and unexplored source of assessing new drug. The purpose of this study was to determine antibacterial activity of methanol extract and essential oil of aerial part of Achillea wilhelmsii against bacteria.

Materials and Methods: Achillea wilhelmsii C-Koch is an endemic plant that has relatively wide distribution in different parts of Iran. The concentrations of 20, 30, 50 and 400 mg/ml of methanol extract were prepared. Antibacterial activities were examined by agar dilution and well diffusion methods against Staphylococcus aureus, Bacillus cereus, E. coli and Pseudomonas aeroginosa. Minimum Inhibitory Concentration (MIC) or Minimum Bactericidal Concentration (MBC) was carried out by tube dilution and well-diffusion methods.

Results: Methanol extracts exhibited inhibitory effects on S. aureus, B. cereus and E. coli with a range of MIC values extended from 6.25 to 25 mg/ml. Essential oil at concentration of 1000µg/ml was active against S. aureus , B. cereus and E. coli. They did not have any activity on P. aeroginosa.

Conclusion: Methanol extract and essential oil of aerial part of Achillea wilhelmsii inhibited growth of pathogenic bacteria especially gram positive bacteria. Clinical applications of these materials needed further investigations.

Keywords

Achillea wilhelmsii

antibacterial activity

plant extract

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