Abstract
Background: Cytokines play an important role during labor of full – or pretern delivery. In umbilical cord blood, Interleukin-6 (IL-6) was thought to be a marker of defense to stress, surgery and infection. The aim of this study was to investigate the cytokine IL-6 concentrations in the mother and neonate depends on the mode of the delivery.
Materials and Method: This study was done on mothers and neonates in 80 single term deliveries (vaginal and cesarean) in Mahdieh Hospital in Tehran. Age of mothers was 21-39 years old, parity was 1 and 2. There wasn't history of underlying disease and drug usage in mothers and neonate was AGA and apgar was more than 8. There wasn't clinical evidence of infection in neonate and mothers. IL-6 was evaluated by enzyme-immunoassays in maternal serum and neonatal umbilical cord. Data were analyzed with SPSS and were applied fishers exact test for compare means.
Results: There were 37 vaginal deliveries and 43cesarean section. The mean (±standard error) of maternal IL-6 concentration in vaginal delivery (0.18±0.02) was significantly (P=0.000) higher than cesarean section (0.1±0.02) and neonatal IL-6 concentration in vaginal delivery (0.17±0.03) was significantly (P=0.000) higher than cesarean section (0.07±0.01).
Conclusion: Results show that vaginal delivery cause to increase IL-6 compared to cesarean section in mother and neonate.
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Copyright
© 2011, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.