Antibiotic resistance of Neisseria gonorrhoeae isolated from gonorrhoeae patients

Mohammad  Bokaeian; Mazhar Iqbal-Qureshi; Soroush Dabiri

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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Antibiotic resistance of Neisseria gonorrhoeae isolated from gonorrhoeae patients

Author(s):

Mohammad Bokaeian^1,*,

Mazhar Iqbal-Qureshi²,

Soroush Dabiri²

1Assistant Professor, Dept. of Laboratory Sciences, School of Paramedical Sciences, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

2MSc, Dept. of Laboratory Sciences, School of Paramedical Sciences, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 12, issue 2; e94309

Published online:May 14, 2010

Article type:Research Article

Received:Sep 26, 2009

Accepted:Dec 12, 2009

How to Cite:Mohammad BokaeianMazhar Iqbal-QureshiSoroush DabiriAntibiotic resistance of Neisseria gonorrhoeae isolated from gonorrhoeae patients.Zahedan J Res Med Sci.12(2):e94309.

Abstract

Background: The objective of this study was to determine antibiotic susceptibility and penicillinase production by Neisseria gonorrhoeae strains isolated from gonorrhoeae patients in Zahedan.

Materials and methods: In a descriptive study during 2005-2008 years, 400 suspected patients were studied by history review, medical examination, gram staining and culture in Thayer-Martin medium. Antibiotic susceptibility and penicillinase tests of isolated strains were done by disk diffusion method and aciodometric method, respectively.

Results: Cultures were positive in 77(19.2%) patients. The resistanat rate against antibiotics were as follow: penicillin (79.2%), ciprofloxacin (53.2%), ceftriaxone(3.8%), spectinomycin(2.5%), cefixime(12.9%), co-trimoxazole(93.5%), tetracycline(88.3%) and gentamicin(29.8%). In the meanwhile, 83.1 percent of penicillin resistant isolates produced penicillinase enzyme.

Discussion: Ceftriaxone, spectinomycin and cefixime are the sole antibiotics that could be considered as selective drugs. Quinolones which were regarded as an effective group of antibiotics recently have lost their importance. Resistance against other antibiotics is rapidly developing, thus, conducting experimental tests and determination of minimum inhibitory concentration and clinical trial studies at fixed intervals can contribute to diagnosis of resistance of gonococci and rapid and successful treatment of their infections in Zahedan region.

Keywords

Neisseria gonorrhoeae

Gonorrhea

Penicillinase

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