Comparison between uterine bleeding and spotting pattern in menopausal women using tibolone, HRT and calcium supplement

authors:

avatar Raziyeh Masoumi 1 , avatar Saeedeh Ziaei 2 , * , avatar Soghrat Faghihzade 3

MSC of midwifery, Tarbiat Modares University, Tehran, Iran.
Professor of Midwifery, Tarbiat Modares University, Tehran, Iran.
Professor of Biostatics, Tarbiat Modares University, Tehran, Iran.
Zahedan Journal of Research in Medical Sciences: Vol.12, issue 2; e94311
published online: May 20, 2010
article type: Research Article
received: October 16, 2009
accepted: January 04, 2010

how to cite: Masoumi R, Ziaei S, Faghihzade S. Comparison between uterine bleeding and spotting pattern in menopausal women using tibolone, HRT and calcium supplement. Zahedan J Res Med Sci. 2010;12(2):e94311. 

Abstract

Background: Steroid hormones play an important role in the treatment of menopausal complications therefore, nowadays there are new drugs having protective effects on endometer. The objective of this study was to compare the amount of uterine bleeding and spotting in patients who consume tibolone versus classic HRT.
  Material and Methods: This�clinical trial has done on 150 menopausal women divided in to three therapeutic groups. Each group took either of three regimens: tibolone, classical HRT and calcium supplement (control group) for six months. The number of the times and length of bleeding and spotting was recorded at the end of the first and second quarterly of treatment.
  Results: Wilcoxon test did not reveal any meaningful differences between the tow groups of tibolone and calcium group. In terms of above mentioned variables in the two mentioned periods. However, in the HRT group, spotting duration had decreased (p=0.04) in the second three months regarding the first quarter. Kruskal-Wallis test indicated a significant difference in all the variables during the first three months of treatment and Mann-Whitney U test, used to determine discrepancy between the involved groups. It has been shown that the average number of the times (p=0.03) and spotting duration (p=0.008) in the HRT group in comparison with tibolone, also the number of the times (p=0.02) and the length of bleeding (p=0.003) in the HRT group was more than that of calcium group. It also revealed that the average of the length of spotting in the tibolone was more (p=0.001) but less in terms of the number of times of spotting in calcium group (p=0.001).
  Discussion: The findings of the study indicated decease in the number of the times and the length of bleeding and spotting period in tibolone group in comparison with classical HRT.

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