Abstract
Background: Myocardial infarction (MI) is one of the most common causes of hospitalization of
patients in western countries. Recently, the role of infectious factors such as Helicobacter pylori as
a risk factor for cardiovascular disease has been suggested. This study was conducted to determine
whether previous exposure to H. pylori is associated with an increased risk for myocardial
infarction.
Materials and Methods: This case-control study was performed on 100 hospitalized patients (50
cases and 50 controls) in Shahid Beheshti hospital of Kashan in 2006. Three milliliter blood was
obtained from each of 50 survivors of acute myocardial infarction (case) and 50 controls with no
history of coronary heart disease and then Anti H. pylori antibody was examined by ELISA. Using
chi-square and Fisher exact test the results were analyzed and P value less then 0.05 was
considered significant.
Results: Nine patients (18%) were seronegative, 5(10%) borderline and 36(72%) seropositive for
Anti-H.plyori antibodies in case group, where as in controls these proportions were 14(28%),
10(20%) and 26(52%), respectively. No significant association was noted between H pylori
seropositivity and risk of MI (P value=0.11).The mean of titer of antibody was 22.6 ±19.8 in
controls and 35.9±31.8 in cases and there was significant correlation between them (P
value<0.001).
Conclusion: This study revealed no association between MI and H. pylori seropositivity. To show
a causal association, very large randomized trials would be needed.
patients in western countries. Recently, the role of infectious factors such as Helicobacter pylori as
a risk factor for cardiovascular disease has been suggested. This study was conducted to determine
whether previous exposure to H. pylori is associated with an increased risk for myocardial
infarction.
Materials and Methods: This case-control study was performed on 100 hospitalized patients (50
cases and 50 controls) in Shahid Beheshti hospital of Kashan in 2006. Three milliliter blood was
obtained from each of 50 survivors of acute myocardial infarction (case) and 50 controls with no
history of coronary heart disease and then Anti H. pylori antibody was examined by ELISA. Using
chi-square and Fisher exact test the results were analyzed and P value less then 0.05 was
considered significant.
Results: Nine patients (18%) were seronegative, 5(10%) borderline and 36(72%) seropositive for
Anti-H.plyori antibodies in case group, where as in controls these proportions were 14(28%),
10(20%) and 26(52%), respectively. No significant association was noted between H pylori
seropositivity and risk of MI (P value=0.11).The mean of titer of antibody was 22.6 ±19.8 in
controls and 35.9±31.8 in cases and there was significant correlation between them (P
value<0.001).
Conclusion: This study revealed no association between MI and H. pylori seropositivity. To show
a causal association, very large randomized trials would be needed.
Keywords
Anti Helicobacter pylori Antibody Acute myocardial infarction Kashan
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© 2009, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.