prognosis of hepatitis B. The present study was conducted to determine the liver function indices
and sonographic findings of chronic hepatitis B (CHB) in HBeAg-negative and HBeAg-positive
Materials and Methods: This Historical Cohort study was conducted on 234 patients with active
CHB (117 HBeAg-negative and 117 HBeAg-positive) in 2007. The patients who were referred to
Hepatitis Clinic of Blood Transfusion Organization were included in the study.
Results: One hundred eighty patients were male, majority of them were resident of Sistan
province and married. The mean age of patients with CHB HBeAg-negative was more than patient
with CHB HBeAg-positive (38.03±11.1 vs 28.77±9.8). There were no significant difference in
Bilirubin, Albumin, ALT and AST levels and also PT between the two groups, but a significant
difference in sonographic findings of liver was demonstrated between two groups.
Conclusion: Based on our results, it is recommended to use other diagnostic indices including
virologic parameters and histopathology to distinguish CHB patients.
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