A Comparison of Effects of lidocaine 5%، lidocaine 5% plus pethidine 5% and pethidine 5% in spinal anesthesia for cesarean section.

hassan enayati; Zahra Moodi; Alireza Dashipoor; AR Shahsavani; Kourosh Tirgar Fakheri

Zahedan Journal of Research in Medical Sciences

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A Comparison of Effects of lidocaine 5%، lidocaine 5% plus pethidine 5% and pethidine 5% in spinal anesthesia for cesarean section.

Author(s):

hassan enayati^1,*,

Zahra Moodi¹,

Alireza Dashipoor²,

AR Shahsavani³,

Kourosh Tirgar Fakheri¹

1Dept of Anesthesiology, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services Zahedan, Iran.

2Dept of Nutrition, Faculty of Medicine, Zahedan University of Medical Sciences and Health Services، Zahedan, Iran.

3Dept of Nursing, Faculty of Nursing & Midwifery, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 9, issue 2; e94814

Published online:Feb 17, 2007

Article type:Research Article

Received:Jul 16, 2006

Accepted:Dec 23, 2006

How to Cite:hassan enayatiZahra MoodiAlireza DashipoorAR ShahsavaniKourosh Tirgar FakheriA Comparison of Effects of lidocaine 5%، lidocaine 5% plus pethidine 5% and pethidine 5% in spinal anesthesia for cesarean section..Zahedan J Res Med Sci.2007;9(2):e94814.

Abstract

Background: Spinal anesthesia for elective cesarean section using drugs such as lidocaine has
long been used with reports of various complications. To reduce these complications, many
methods such as administration of sympathetic stimulating drugs like ephedrine, and using other
drugs including pethidine have been recommended. The present study was aimed to evaluate
comparatively the effects of separate and combined administration of pethidine and lidocaine on
spinal anesthesia in candidates for cesarean surgery.
Material and Methods: In this double blind clinical trial study, 150 cases with ASA I – II and
full term neonatal, candidate for elective cesarean surgery from Zahedan Ghods Hospital and Ali-
Ebene-Abitaleb Hospital, were subjected to the study during 2001-2004. They were randomly
divided into three groups of 50, for using 5% lidocaine, 5% lidocaine plus 5% pethidine and 5%
pethidine, respectively. A number of variables, including duration of postoperative analgesia,
variation of homodynamic, heart rate, hypotension, nausea and vomiting were assessed. Statistical
descriptive methods, one way ANOVA and X2 were used for the data analysis.
Results: Breath depression was not seen in the neonates. The Apgar score was ≥8. Duration of
post operating analgesia was 453 minutes in pethidine group, 344.3 minutes in lidocaine plus
pethidine group and 141.4 minutes in lidocaine group with significant differences (P<0.05).
Differences of nausea and vomiting between groups were not significant.
Conclusion: The longest duration of analgesia was seen with pethidine usage. The combination
of pethidine and lidocaine was intermediately effective and seems to be suitable choice in
anesthesia comparing to lidocaine alone.

Keywords

lidocaine

pethidine

spinal anesthesia.

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References

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