Abstract
Background: Spinal anesthesia for elective cesarean section using drugs such as lidocaine has
long been used with reports of various complications. To reduce these complications, many
methods such as administration of sympathetic stimulating drugs like ephedrine, and using other
drugs including pethidine have been recommended. The present study was aimed to evaluate
comparatively the effects of separate and combined administration of pethidine and lidocaine on
spinal anesthesia in candidates for cesarean surgery.
Material and Methods: In this double blind clinical trial study, 150 cases with ASA I – II and
full term neonatal, candidate for elective cesarean surgery from Zahedan Ghods Hospital and Ali-
Ebene-Abitaleb Hospital, were subjected to the study during 2001-2004. They were randomly
divided into three groups of 50, for using 5% lidocaine, 5% lidocaine plus 5% pethidine and 5%
pethidine, respectively. A number of variables, including duration of postoperative analgesia,
variation of homodynamic, heart rate, hypotension, nausea and vomiting were assessed. Statistical
descriptive methods, one way ANOVA and X2 were used for the data analysis.
Results: Breath depression was not seen in the neonates. The Apgar score was ≥8. Duration of
post operating analgesia was 453 minutes in pethidine group, 344.3 minutes in lidocaine plus
pethidine group and 141.4 minutes in lidocaine group with significant differences (P<0.05).
Differences of nausea and vomiting between groups were not significant.
Conclusion: The longest duration of analgesia was seen with pethidine usage. The combination
of pethidine and lidocaine was intermediately effective and seems to be suitable choice in
anesthesia comparing to lidocaine alone.
long been used with reports of various complications. To reduce these complications, many
methods such as administration of sympathetic stimulating drugs like ephedrine, and using other
drugs including pethidine have been recommended. The present study was aimed to evaluate
comparatively the effects of separate and combined administration of pethidine and lidocaine on
spinal anesthesia in candidates for cesarean surgery.
Material and Methods: In this double blind clinical trial study, 150 cases with ASA I – II and
full term neonatal, candidate for elective cesarean surgery from Zahedan Ghods Hospital and Ali-
Ebene-Abitaleb Hospital, were subjected to the study during 2001-2004. They were randomly
divided into three groups of 50, for using 5% lidocaine, 5% lidocaine plus 5% pethidine and 5%
pethidine, respectively. A number of variables, including duration of postoperative analgesia,
variation of homodynamic, heart rate, hypotension, nausea and vomiting were assessed. Statistical
descriptive methods, one way ANOVA and X2 were used for the data analysis.
Results: Breath depression was not seen in the neonates. The Apgar score was ≥8. Duration of
post operating analgesia was 453 minutes in pethidine group, 344.3 minutes in lidocaine plus
pethidine group and 141.4 minutes in lidocaine group with significant differences (P<0.05).
Differences of nausea and vomiting between groups were not significant.
Conclusion: The longest duration of analgesia was seen with pethidine usage. The combination
of pethidine and lidocaine was intermediately effective and seems to be suitable choice in
anesthesia comparing to lidocaine alone.
Keywords
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Copyright
© 2007, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.