Abstract
Background: Several clinical studies have recently claimed that HCV infection could trigger the
onset of diabetes mellitus (DM). In order to determine the prevalence of hepatitis C virus (HCV)
among patients with type 1, 2 diabetes mellitus (DM) and investigate the influence of several
epidemiological factors on HCV infection, we conducted this study.
Materials and Methods: In this case-control study we evaluated 505 diabetic patients (135 male,
370 female with the mean age of 54.5 years) who had referred to Diabetic clinic in Boo-Ali hospital
(a teaching hospital in south east of Iran) in 2004. Serologic testing for anti- HCV was done using a
third–generation commercial Enzyme–Linked Immunosorbent Assay (ELISA) and Real–time–PCR
(HCV RNA) in order to confirm the anti-HCV positive samples. Diabetic patients were divided in
two groups according to their HCV antibody status and were analyzed for the following variables:
age, sex, type of diabetes, duration of disease, mode of therapy, late diabetic complication, previous
blood transfusions, intravenous drug addiction, hospital admissions and major surgical procedures.
Then results were compared with the findings from blood donors.
Results: HCV infection was detected in one patient who had history of hospitalization and blood
transfusion. However, a higher prevalence of HCV infection was not observed in diabetic patients
in comparison with blood donors (P=0.46).There was no correlation between HCV and diabetic
type, duration, age, sex (P>0.05).
Conclusions: Upon the results of our study, we conclude that HCV infection is not a trigger
factor for DM; therefore it should not be listed among the various extrahepatic manifestations of
this viral infection. Although, further studies, possibly multicentre, are needed to estimate
prevalence of HCV in diabetic patients.
onset of diabetes mellitus (DM). In order to determine the prevalence of hepatitis C virus (HCV)
among patients with type 1, 2 diabetes mellitus (DM) and investigate the influence of several
epidemiological factors on HCV infection, we conducted this study.
Materials and Methods: In this case-control study we evaluated 505 diabetic patients (135 male,
370 female with the mean age of 54.5 years) who had referred to Diabetic clinic in Boo-Ali hospital
(a teaching hospital in south east of Iran) in 2004. Serologic testing for anti- HCV was done using a
third–generation commercial Enzyme–Linked Immunosorbent Assay (ELISA) and Real–time–PCR
(HCV RNA) in order to confirm the anti-HCV positive samples. Diabetic patients were divided in
two groups according to their HCV antibody status and were analyzed for the following variables:
age, sex, type of diabetes, duration of disease, mode of therapy, late diabetic complication, previous
blood transfusions, intravenous drug addiction, hospital admissions and major surgical procedures.
Then results were compared with the findings from blood donors.
Results: HCV infection was detected in one patient who had history of hospitalization and blood
transfusion. However, a higher prevalence of HCV infection was not observed in diabetic patients
in comparison with blood donors (P=0.46).There was no correlation between HCV and diabetic
type, duration, age, sex (P>0.05).
Conclusions: Upon the results of our study, we conclude that HCV infection is not a trigger
factor for DM; therefore it should not be listed among the various extrahepatic manifestations of
this viral infection. Although, further studies, possibly multicentre, are needed to estimate
prevalence of HCV in diabetic patients.
Keywords
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Copyright
© 2006, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.