Non-HDL-C versus LDL-C for screening of hyperlipidemic patients


avatar AA Rakhshani 1 , * , avatar Masoud Salehi 2

Cardiologist Dept, Paramedical School, Zahedan University of Medical Science and health services, Zahedan, Iran.
Tropical and Infectious Diseases Dept, Faculty of Medicine, Zahedan University of Medical Sciences and health services, Zahedan, Iran.

how to cite: Rakhshani A, Salehi M. Non-HDL-C versus LDL-C for screening of hyperlipidemic patients. Zahedan J Res Med Sci. 2006;8(2):e94899.


Background: Measurement of the plasma lipids is an essential component of prophylactic
medicine. The current screening test for prediction of cardiovascular complications due to
hyperlipidemia is LDL-C measurement through Friedwald formula. This test becomes progressively
less accurate as plasma TG increases. The test is inapplicable in TG over 400. The measurement of
non-HDL-C versus LDL-C in screening of hyperlipidemic patients is the aim of this study.
Materials and Methods: In a descriptive analytic study we divided 1000 patients (20-60 years old)
who referred to two laboratories in Zahedan Into five groups according to their TG levels. HDL-C
(with Friedwald Formula), non-HDL-C, the correlation between HDL-C and plasma cholesterol
level, the correlation between non-HDL-C and plasma cholesterol level were determined in each
Results: The findings revealed that the correlation between LDL-C and plasma cholesterol level
decreases as TG level increases. At TG levels less than 400 mg/dl the correlation between LDL and
non-HDL was not significant but was at TG levels over 400.
Conclusion: It is inferred that we can use non-HDL instead of LDL-C (at any TG level) in order
to screening of hyperlipidemic patients without fasting. It is still necessary to measure TG level for
appropriate drug selection.


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