Abstract
Background: Gastric cancer is the second most common cause of cancer related death in the
world. Helicobacter pylori infection is associated with chronic gastritis, a known precursor of
gastric cancer. Carcinomas have been shown to be related to a high prevalence of H.Pylori
infection. We study titer of H.Pylori antibody in patients with gastric cancer and in patients with
non-ulcer dyspepsia.
Methods and Materials: During an eleven-month course (October 2001- September 2002) we
studied the relation between H. Pylori infection and gastric carcinoma in a case - control study in
Zahedan hospitals. The subjects divided into two groups; 40 control subjects and 40 patients with
gastric carcinoma. IgG Antibody to H. Pylori was checked in serum of patients in both groups by
ELISA method.
Results: Each group comprised of 21 male (52.5%) and 19 female (47.5%). Mean age was 53.18
and 56.58 years in control and case group, respectively. Anti-H. Pylori IgG was positive in 100% of
patients with gastric carcinoma but only in 28% of the control subjects. Chi-test demonstrated a
significant correlation between gastric cancer and Antibody test. (P= 0.000). Patients with gastric
carcinoma had higher titer of IgG 85.67 in contrast to those who did not have cancer.
Conclusions: Like other epidemiologic studies this study revealed that H. pylori infection is
associated with an increased risk of gastric carcinoma and is considered as a cofactor in the
pathogenesis of this malignant condition.
world. Helicobacter pylori infection is associated with chronic gastritis, a known precursor of
gastric cancer. Carcinomas have been shown to be related to a high prevalence of H.Pylori
infection. We study titer of H.Pylori antibody in patients with gastric cancer and in patients with
non-ulcer dyspepsia.
Methods and Materials: During an eleven-month course (October 2001- September 2002) we
studied the relation between H. Pylori infection and gastric carcinoma in a case - control study in
Zahedan hospitals. The subjects divided into two groups; 40 control subjects and 40 patients with
gastric carcinoma. IgG Antibody to H. Pylori was checked in serum of patients in both groups by
ELISA method.
Results: Each group comprised of 21 male (52.5%) and 19 female (47.5%). Mean age was 53.18
and 56.58 years in control and case group, respectively. Anti-H. Pylori IgG was positive in 100% of
patients with gastric carcinoma but only in 28% of the control subjects. Chi-test demonstrated a
significant correlation between gastric cancer and Antibody test. (P= 0.000). Patients with gastric
carcinoma had higher titer of IgG 85.67 in contrast to those who did not have cancer.
Conclusions: Like other epidemiologic studies this study revealed that H. pylori infection is
associated with an increased risk of gastric carcinoma and is considered as a cofactor in the
pathogenesis of this malignant condition.
Keywords
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Copyright
© 2005, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.