The comparison of titer of Helicobacter Pylori antibody in patients with gastric carcinoma and control group in Zahedan

SK Nezam; H Rahimi

Zahedan Journal of Research in Medical Sciences

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The comparison of titer of Helicobacter Pylori antibody in patients with gastric carcinoma and control group in Zahedan

Author(s):

SK Nezam^1,*,

H Rahimi²

1Internal Medicine Dept, Faculty of Medicine, Zahedan University of Medical Science and health services, Zahedan, Iran.

2Assistant of Internal Medicine Dept, Faculty of Medicine, Zahedan University of Medical Science and health services, Zahedan, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 7, issue 4; e94922

Published online:Oct 26, 2004

Article type:Research Article

Received:Dec 14, 2003

Accepted:Feb 26, 2004

How to Cite:SK NezamH RahimiThe comparison of titer of Helicobacter Pylori antibody in patients with gastric carcinoma and control group in Zahedan.Zahedan J Res Med Sci.7(4):e94922.

Abstract

Background: Gastric cancer is the second most common cause of cancer related death in the
world. Helicobacter pylori infection is associated with chronic gastritis, a known precursor of
gastric cancer. Carcinomas have been shown to be related to a high prevalence of H.Pylori
infection. We study titer of H.Pylori antibody in patients with gastric cancer and in patients with
non-ulcer dyspepsia.
Methods and Materials: During an eleven-month course (October 2001- September 2002) we
studied the relation between H. Pylori infection and gastric carcinoma in a case - control study in
Zahedan hospitals. The subjects divided into two groups; 40 control subjects and 40 patients with
gastric carcinoma. IgG Antibody to H. Pylori was checked in serum of patients in both groups by
ELISA method.
Results: Each group comprised of 21 male (52.5%) and 19 female (47.5%). Mean age was 53.18
and 56.58 years in control and case group, respectively. Anti-H. Pylori IgG was positive in 100% of
patients with gastric carcinoma but only in 28% of the control subjects. Chi-test demonstrated a
significant correlation between gastric cancer and Antibody test. (P= 0.000). Patients with gastric
carcinoma had higher titer of IgG 85.67 in contrast to those who did not have cancer.
Conclusions: Like other epidemiologic studies this study revealed that H. pylori infection is
associated with an increased risk of gastric carcinoma and is considered as a cofactor in the
pathogenesis of this malignant condition.

Keywords

Helicobacter Pylori

Gastric cancer

Chronic gastritis

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