Study on Neisseria gonorrhoeae antibiogram and its resistance to Quinolones and third generation Cephalosporins in men with gonococcal urethritis

Background: Gonococcal urethritis is one of the most common STDs in men, which in spite of
expanded antibiotic therapies, is widespread over the world, the incidence of cases resistant
antibacterial components is among the causes for recurrence of gonococcal diseases. This study
aims at determining sensitivity of gonococcus to common antimicrobial in its treatment such as
Penicillin, Sephalesporins, felodokinolos. Therefore, in this study in vitro-evaluation resistance of
this organism to different antibiotic especially 3rd generation which have been used as selected
medicine for the treatment of gonococcal infections in recent years and cases resistant to the
treatment have been report recently was conducted as a background for clinical trials.
Methods and Materials: In this study, the in vitro resistance rates of Neisseria gonorrhoeae to
various antibiotics by using disk diffusion method have been assessed. The study is a cross sectional
descriptive one, on 200 culture positive samples during 2 years (2003-2004) in medical laboratory.
For analyzing of data, chi-square test was used.
Results: Resistance of Neisseria gonorrhoeae to antibiotics were as follows: Ampicillin: 96%,
Amoxicillin: 92.5%, Co-trimoxasole: 92%, Gentamycin: 89%, Amikacin: 88%, Erythromycin: 85%,
Penicillin: 75.5, Tetracycline 59.5%, Ciprofloxacin: 46.5%, Cefixime 15%, and Ceftriaxone 2.5%.
Conclusions: The result showed that ceftriaxone and probably other Sefalosparins of 3rd
generation including oral and injections is, presently, the sole group that can be considered as a
select drug. Felorokinolons which were regarded as an effective drug until very recently, have lost
their importance. This result is in conformity with regional and international studies. Hence,
conducting experimental test, particularly E. test E pisilometery test and determination of (minimal
inhibitory MIC concentration) and later clinical experiences at fixed intervals can contribute to
diagnosis of resistance of Neisseria to antimicrobial component ion oerliminary stages that can
decrease irrational consumption of drug in the treatment of clinical syndrome of Nesseria
gonorrhea.