Comparing high dose vitamin B6 with corticotherapy in infantile spasm

authors:

avatar Mohsen Javadzadeh 1 , * , avatar M Mohavalati 2 , avatar M Ghofrani 2

Pediatric disease dept, Faculty of medicine, Zahedan University of Medical Sciences and health services, Zahedan, Iran.
Pediatric disease dept, Faculty of medicine, Shahid Beheshti University of Medical Sciences and health services, Tehran, Iran.
Zahedan Journal of Research in Medical Sciences: Vol.6, issue 3; e94992
published online: September 05, 2004
article type: Research Article
received: June 18, 2004
accepted: August 25, 2004

how to cite: Javadzadeh M, Mohavalati M, Ghofrani M. Comparing high dose vitamin B6 with corticotherapy in infantile spasm. Zahedan J Res Med Sci. 2004;6(3):e94992. 

Abstract

Background: Since present available treatments for infantile spasms (IS) are far from adequate,
and also side effects of the current therapeutic regimens are frequent and serious, the ongoing
search for better protocols is understandable.
Methods and Materials: We compared the therapeutic and adverse effects of vitamin B6 given in
high doses with prednisolone in a randomized controlled double blind clinical trial. Vitamin B6
(40mg/kg/24hr) and prednisolone (1.5mg/kg/day) were tried in 22 and 15 patients respectively, and
the patients were followed for at least 6 months.
Results: Response to treatment was slightly better in the prednisolone group but the difference
was not significant (P=0.4). On the other hand adverse effects were also seen more frequently with
prednisolone.
Conclusions: We conclude that high dose vitamin B6 should be looked at as a justified and worthtrying
method of treatment. It seems that it can be safely used where there is contraindication to use
other antiepileptic drugs or where they have failed, and even in fresh cases of IS.

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References

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