Comparing high dose vitamin B6 with corticotherapy in infantile spasm

Mohsen Javadzadeh; M Mohavalati; M Ghofrani

Zahedan Journal of Research in Medical Sciences

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Comparing high dose vitamin B6 with corticotherapy in infantile spasm

Author(s):

Mohsen Javadzadeh^1,*,

M Mohavalati²,

M Ghofrani²

1Pediatric disease dept, Faculty of medicine, Zahedan University of Medical Sciences and health services, Zahedan, Iran.

2Pediatric disease dept, Faculty of medicine, Shahid Beheshti University of Medical Sciences and health services, Tehran, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 6, issue 3; e94992

Published online:Sep 05, 2004

Article type:Research Article

Received:Jun 18, 2004

Accepted:Aug 25, 2004

How to Cite:Mohsen JavadzadehM MohavalatiM GhofraniComparing high dose vitamin B6 with corticotherapy in infantile spasm.Zahedan J Res Med Sci.6(3):e94992.

Abstract

Background: Since present available treatments for infantile spasms (IS) are far from adequate,
and also side effects of the current therapeutic regimens are frequent and serious, the ongoing
search for better protocols is understandable.
Methods and Materials: We compared the therapeutic and adverse effects of vitamin B6 given in
high doses with prednisolone in a randomized controlled double blind clinical trial. Vitamin B6
(40mg/kg/24hr) and prednisolone (1.5mg/kg/day) were tried in 22 and 15 patients respectively, and
the patients were followed for at least 6 months.
Results: Response to treatment was slightly better in the prednisolone group but the difference
was not significant (P=0.4). On the other hand adverse effects were also seen more frequently with
prednisolone.
Conclusions: We conclude that high dose vitamin B6 should be looked at as a justified and worthtrying
method of treatment. It seems that it can be safely used where there is contraindication to use
other antiepileptic drugs or where they have failed, and even in fresh cases of IS.

Keywords

Vitamin B6

Prednisolone

Infantile spasm

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References

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