The evaluation of HLA class II association With allergic asthma

Ebrahim Alijani; M Shekarabi; M Kamgooyan; S Arshi

Zahedan Journal of Research in Medical Sciences

The Official Journal of Zahedan University of Medical Sciences

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The evaluation of HLA class II association With allergic asthma

Author(s):

Ebrahim Alijani^1,*,

M Shekarabi²,

M Kamgooyan³,

S Arshi⁴

1Immunoheamatology Dept‚ Faculty of Medicine ‚ Zahedan University Of Medical Sciences and health services, Zahedan ‚ Iran.

2Immunomicrobiology Dept‚ Faculty of Medicine, Iran University of Medical Sciences and health services, Tehran, Iran.

3Transplantation Dept, Tehran center of blood transfusion‚Tehran‚ Iran.

4Immunology and Allergy Dept‚ Amiralmomenin Hospital ‚ Iran University of Medical Sciences and health services, Tehran, Iran.

Zahedan Journal of Research in Medical Sciences:Vol. 5, issue 2; e95143

Published online:Jun 25, 2003

Article type:Research Article

Received:Jun 12, 2003

Accepted:Jun 16, 2003

How to Cite:Ebrahim AlijaniM ShekarabiM KamgooyanS ArshiThe evaluation of HLA class II association With allergic asthma.Zahedan J Res Med Sci.5(2):e95143.

Abstract

Major histocompatibility complex (MHC)‚ which plays a major biological function in immune
response is generally associated with so many human diseases. During recent years a strong
relationship between allergic diseases and HLA antigens have been demonstrated.
This study was done to investigate the relationship between allergic asthma and HLA antigens
in Iranian’s atopic asthmatic patients. This case control study was done on 30 atopic asthmatic
patients and healthy controls in 1376 in Tehran.
Human leukocyte antigen (HLA) typing was performed by standard N.I.H procedures and the
results analyzed.
The results of this study showed that there is a significant relation between allergic asthma and
some of class II HLA antigens i.e: frequency of DR2 and DR53 antigen in patient group in
comparison with healthy group has been increased and frequency of DR5, DR11, DR52 and DQ1
has been decreased.

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