Abstract
Major histocompatibility complex (MHC)‚ which plays a major biological function in immune
response is generally associated with so many human diseases. During recent years a strong
relationship between allergic diseases and HLA antigens have been demonstrated.
This study was done to investigate the relationship between allergic asthma and HLA antigens
in Iranian’s atopic asthmatic patients. This case control study was done on 30 atopic asthmatic
patients and healthy controls in 1376 in Tehran.
Human leukocyte antigen (HLA) typing was performed by standard N.I.H procedures and the
results analyzed.
The results of this study showed that there is a significant relation between allergic asthma and
some of class II HLA antigens i.e: frequency of DR2 and DR53 antigen in patient group in
comparison with healthy group has been increased and frequency of DR5, DR11, DR52 and DQ1
has been decreased.
response is generally associated with so many human diseases. During recent years a strong
relationship between allergic diseases and HLA antigens have been demonstrated.
This study was done to investigate the relationship between allergic asthma and HLA antigens
in Iranian’s atopic asthmatic patients. This case control study was done on 30 atopic asthmatic
patients and healthy controls in 1376 in Tehran.
Human leukocyte antigen (HLA) typing was performed by standard N.I.H procedures and the
results analyzed.
The results of this study showed that there is a significant relation between allergic asthma and
some of class II HLA antigens i.e: frequency of DR2 and DR53 antigen in patient group in
comparison with healthy group has been increased and frequency of DR5, DR11, DR52 and DQ1
has been decreased.
Keywords
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Copyright
© 2003, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0) (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.