Measurement of Tuberculin Skin Test

Author(s):
Jamshid AyatollahiJamshid Ayatollahi1,*
1Infectious and Tropical Diseases Research Center, Yazd University of Medical Sciences, Yazd, Iran
*Corresponding Author: Infectious and Tropical Diseases Research Center, Yazd University of Medical Sciences, Yazd, Iran. Email:, [email protected]. Email: [email protected]

Archives of Clinical Infectious Diseases:Vol. 1, issue 4; 187-9
Published online:Oct 31, 2006
Article type:Research Article
How to Cite:Ayatollahi J. Measurement of Tuberculin Skin Test. Arch Clin Infect Dis. 2006;1(4):. doi:

Abstract

Current guidelines suggest that the PPD Mantoux tuberculin test should be read after 48 or 72 hours. We have compared the measurements at these time points.

A 5-tuberculin unit (TU) PPD Mantoux test was administered to 100 subjects (91% with Bacillus Calmette- Guerin scars). Induration was measured 48 and 72 hours following the injection.

Results:

The measurements made at 72nd hour were significantly higher than those made at 48th hour (median: 8.9 vs 4.5mm, p=0.01). In those subjects with indurations at either or both time points (n=74), the readings taken at 72nd hour were on average 2.1mm (95% confidence interval: 0.3-3.1mm) larger than those at 48th hour. Using an induration of>15mm diameter to define a positive result, there were more positive test results at 72nd hour (24) compared to 48th hour (20).

Conclusion:

We concluded that, in adults, the size of the 5-TU Mantoux reaction is significantly larger at 72nd hour, thus, in clinical practice, tuberculin tests should be read at this time point since negative tests at 48th hour may be false negative.

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Copyright

© 2006, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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