Chronic diseases are responsible for more than 35 million deaths each year, accounting for nearly two-thirds of all global mortality (
1). Individuals with chronic diseases often experience repeated treatments and prolonged hospitalizations, which expose them to a range of physical, psychological, social, and economic challenges, including pain, depression, social isolation, psychological stress, and high medical expenses, all of which significantly diminish their quality of life (
2). Psychological distress is one of the most common problems among individuals with chronic diseases and can significantly affect their quality of life and treatment outcomes. Identifying the factors that contribute to psychological distress and predicting its occurrence can help mental health professionals provide more effective interventions (
3). In this regard, attachment styles and emotion regulation ability are two key factors that may play an important role in predicting psychological distress among individuals with chronic diseases (
4). Attachment styles, which are formed during childhood, significantly shape interpersonal relationships and stress-coping patterns in adulthood (
5). Research indicates that individuals with secure attachment styles have a greater capacity to manage stress and maintain psychological well-being compared with those who exhibit insecure attachment styles (avoidant or anxious) (
6,
7). In a large study involving 1,200 individuals with chronic diseases, 65% of those with secure attachment reported lower levels of psychological distress, whereas this proportion was only 35% among those with insecure attachment styles (
8-
10). Moreover, emotion regulation ability is another critical factor in maintaining psychological well-being and coping with the stressors associated with chronic illnesses (
5). Individuals with stronger emotion regulation skills are generally better equipped to manage the psychological challenges that accompany chronic disease (
2). Studies have shown that training in emotion regulation skills can reduce symptoms of depression and anxiety by up to 40% in individuals with chronic diseases. Similar findings were reported in a study conducted by Brown on patients with cardiovascular diseases. The researchers found that a secure attachment style was associated with stronger emotion regulation abilities and lower levels of psychological distress. They further suggested that enhancing emotion regulation skills could serve as an effective intervention to reduce psychological distress in this patient population (
5). From an economic perspective, research in this area can also offer substantial benefits. Studies indicate that individuals with chronic diseases experiencing psychological distress incur higher healthcare costs and have an increased likelihood of hospital readmission. By predicting and preventing psychological distress in these patients, healthcare expenditures can be reduced by up to 30% (
11). Given the increasing prevalence of chronic diseases in Iran and worldwide, examining the psychological factors that affect the mental health of these patients is of critical importance. A better understanding of the factors contributing to psychological distress, along with the implementation of appropriate interventions, can help these individuals lead a more satisfying life despite the challenges posed by chronic illness.