Substance misuse among youth has become a global social problem (
1). This multifarious public health concern is growing around the world (
2). Hard drinks, tobacco, and opioids are the main substances consumed by youngsters (
2). It is estimated that alcohol, tobacco, and over-the-counter drugs account for 15.1% of the causes of death (
3). Substance misuse causes the highest death rate in global burden of disease. In addition, it ranks the third among the ten causes of death in the world and the second in the central Asian countries (
4). Mental disorder is the common outcome of alcohol addiction (
5). Common mental disorders and attention deficit disorders are associated with anxiety and depression (
6). These mental disorders affect the society, especially family members (
7,
8). It is likely that any drug misuse will have a high impact on the daily living activities of family members (
9). Drug misuse and alcohol intake have caused anxiety, financial issues, poverty, and family life disruptions (
9-
12). Relationship disruptions are common among the family members of nuclear or combined family systems (
12). Another study revealed that family members with drug addiction lack awareness regarding social support (
13). Families with alcohol addiction have experienced higher anxiety and depression than families with only mental disorders without any substance addiction. In addition, families often face difficulties to access medical care. According to the literature, families living with drug addiction are unlikely to know the source of support. Family members also have problems accessing the counselling services and social support. Moreover, they are afraid of social stigma (
14).
This systematic review aimed to determine the risk factors of substance abuse for family function. Moreover, the preventive strategies for substance misuse among young people are evaluated. Identifying preventive predictors related to anxiety resilience can help future research and health providers to maintain family support.