Living healthily in an increasingly industrialized world driven by science and technology is of paramount importance (
1). Consequently, promoting health has become a focal point in healthcare. The rising costs of healthcare services have necessitated a shift from treatment to disease prevention (
2). Scientific research indicates that many chronic diseases are strongly linked to health-promoting behaviors (
3). In this context, new health systems have created evolving needs for their audiences, compelling individuals to adopt new roles in making informed decisions for themselves and their families. One of the most significant factors in this regard is health literacy (
4), which has emerged as a critical issue in global discussions (
5). Health literacy is a crucial factor that influences health outcomes. Low health literacy is associated with an increased risk of emergency care and hospital admissions, higher mortality rates, and poor adherence to medication regimens (
6). The U.S. Ministry of Health and Human Services and the National Academy of Medicine define health literacy as "the degree to which individuals can obtain, process, and understand their basic health information and services to make health decisions" (
7). In essence, health literacy encompasses a set of complex and interconnected skills necessary for individuals to navigate the healthcare environment effectively (
6,
8-
11). These skills impact various aspects of communication, including print literacy — the ability to read, understand, and act upon written materials — locating and interpreting health information in documents, and oral literacy, which involves effectively speaking and listening about health information, such as understanding the needs of healthcare professionals and receiving their guidance (
12). Only 12 percent of the adult population in the United States possesses "excellent" health literacy, while the majority (53%) have "adequate" health literacy (
13). This disparity has been termed the "health literacy epidemic" (
14). Importantly, low health literacy is linked to challenges in communicating about health, including a diminished ability to understand and follow medical advice, increased healthcare costs, and difficulties in interpreting written information in medical and surgical contexts (
12,
15). Nowadays, there is a growing interest in using health literacy systems like mobile health applications to improve the effectiveness of healthcare delivery (
16). Since computing technologies are implemented on mobile devices that cater to the special needs of individuals, mobile health apps are designed to be convenient and efficient, allowing people to access them anytime and anywhere at relatively low costs (
17). According to the Pew Internet and American Life Project, more than half of American adults who own a mobile phone have smartphones, and about 20% of them have downloaded at least one mobile health application (
18). Currently, assessing and evaluating scientific output is one of the most prominent research topics in scientometrics (
19). Citation analysis is one method used to measure research impact in scientometric and bibliometric studies (
20). However, traditional indicators such as the number of citations, journal impact factors, and average citations per article are often inadequate for determining the factors that influence an article's impact (
21). While pioneering works may accelerate citation rates, increases in citations can also stem from controversial or erroneous findings, self-citations, or critiques of the work. Moreover, citation rates do not consider an article's impact on online social networks (
22,
23). The rise of new technologies and social media has rendered traditional bibliometric indicators less effective in reflecting research impact, prompting the adoption of complementary methods like altmetrics (
24,
25). Altmetrics, introduced by Priem et al., utilize social media-based indicators to quantify the social impact of scientific information. This approach has evolved into a research frontier that leverages contributions from the research community (
26). Altmetrics measure the number of times a paper is "mentioned" across various online platforms, including digital news media, blogs, and social media channels like Twitter, Facebook, and YouTube (
27-
31). Compared to traditional bibliometric indicators, such as impact factors and citation, altmetrics provide a more comprehensive assessment of a paper's overall impact (
32). The complexity of modern health systems, the abundance of health-related information, and the increasing burden of chronic diseases demand that individuals take an active role in managing their own health (
33). The integration of ChatGPT and e-health literacy, as an innovative approach to improving access and quality of healthcare services, has the potential to enhance access to health information and health-related decision-making (
34). This shift necessitates a deeper understanding of health information, making health literacy a vital component of public health. The ability to access, comprehend, and use health information effectively is now essential not only for individual well-being but also for the sustainability of healthcare systems (
35). As digital technologies become integral to everyday life, tools like mobile health applications offer innovative pathways to support health literacy. Additionally, assessing the reach and impact of scientific research in this area is key to shaping effective public health strategies and informing policy. Understanding how health literacy initiatives perform — both in scientific discourse and public engagement — has become increasingly important in an era where information is widespread but not always accessible or actionable (
36). In general, analyzing the altmetrics of scientific outputs health literacy promotion systems helps policymakers, research organizations, investors, and academic employers recognize the preliminary evidence of the impact of scientific products on clinical practices, education, and health (
37,
38). A review of the literature shows a lack of altmetric research in this area. Consequently, there is a need to evaluate the productivity and social impact of scientific outputs related to health literacy systems.