Addiction is a disorder with clinical, behavioral, and cognitive symptoms affected by social, psychological, biological, and pharmacological factors; social factors mostly affect onset of substance abuse and biological factors are responsible for maintenance of substance abuse (
1). In spite of the obvious risks and complications of addiction, its victims increase every day and reports by international organizations indicate the rise of substance abuse all over the world (
2). Developing countries has been known to be at higher risk of substance abuse due to their large youth population, where college students like other groups are not supported against the risky factors (
3). Substance abuse is one of the psychological problems among college students (
4). Considering several educational and non-educational side consequences of substance abuse, such as lack of motivation, education failure, physical and mental problems, suicide and aggressive behaviors, lack of identity, and risky sexual behaviors among college students, it seems necessary to design and implement preventive interventions (
3,
5). A major issue in designing preventive interventions is to gain knowledge on the effects of personality factors on predicting substance abuse. In this regard, several studies investigated the association of personality factors such as anxiety, depression, impulsivity, and sensation seeking with substance abuse (
6-
12). For example, Wills emphasized the effects of personality factors, especially sensation seeking, on substance abuse (
6). Grant et al. reported the relationship between alcohol drinking and personality factors of anxiety and depression (
7). Ersche and Kopstein also showed that high rates of sensation seeking increases probability of substance abuse (
8,
9). In addition, some other studies mentioned the role of poor impulsive control in substance abuse (
10,
11). In this regard, Malmberg et al. introduced sensation seeking and impulsivity as strong factors to predict substance abuse, though they rejected the relationship between anxiety and substance abuse (
12). On the other hand, several studies suggested higher rates of substance abuse among men compared to women which shows the importance of considering gender in studies on substance abuse (
13,
14). It seems that knowledge of behavioral science experts on personality factors which predict substance abuse could help planning preventive interventions (
6-
12).