Sodium Valproate as an Adjunctive Drug in Treatment of Schizophrenia

Victoria Omranifard; Afsaneh Karbasi Amel; Siamak Amanat

IJ Psychiatry and Behavioral Sciences

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Sodium Valproate as an Adjunctive Drug in Treatment of Schizophrenia

Author(s):

Victoria Omranifard^1,*,

Afsaneh Karbasi Amel²,

Siamak Amanat²

1Assistant professor of psychiatry, Isfahan Medical University P.O.Box : 81465-993, Isfahan, Iran

2Department of Psychiatry, Research Center of Psychiatry and Behavioral Sciences, Isfahan, Iran

IJ Psychiatry and Behavioral Sciences:Vol. 1, issue 1; 12-5

Published online:Jan 30, 2007

Article type:Research Article

Received:Nov 22, 2006

Accepted:Dec 03, 2006

How to Cite:Omranifard V, Karbasi Amel A, Amanat S. Sodium Valproate as an Adjunctive Drug in Treatment of Schizophrenia. Iran J Psychiatry Behav Sci. 2007;1(1):. doi:

Abstract

Objective: Although sodium valproate came to the market as an anticonvulsant drug, nowadays it's wildly used in the management of psychiatric disorders. It is used as a mood stabilizer and as an adjunctive agent in treatment of depression and psychosis. There are controversies regarding sodium valproate efficacy in psychosis. Although some studies have reported that it is effective in the management of positive symptoms and aggression in acute psychosis, others have not found such an association. Our study aims to investigate the effects of adjunctive sodium valproate in the pharmacological management of patients with schizophrenia.

Method: In a double blind clinical trial, 32 schizophrenic patients (age 18 65), who were in immediate need of admission, were randomly allocated into two groups. The first group was treated by combination of sodium valproate and risperidone and the other by combination of placebo and risperidone. A diagnosis of schizophrenia was established based on DSM-IV-TR criteria. All patients were assessed by PANSS on the 1 st , 14th and 28th days of the admission. The collected data were analyzed by Student and Paired T tests through SPSS.

Results: Comparison of PANSS mean score in two groups, before and after the trial, showed statistically significant differences. The reduction in PANSS score was significantly higher in the group treated with sodium valproate than in placebo group (P= 0.006). Although, there was a statistically significant reduction in positive symptoms in both group after 2 weeks of treatment (P= 0.048), the difference was not significant in the fourth week (P= 0.88)

Conclusion: Our study shows that if used as an adjunct to antipsychotic in the management of acute psychosis, sodium valproate will speed up the recovery of positive symptom

Keywords

Risperidone

Schizophrenia

Valproic Acid

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References

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References are available in the PDF.

Comparison of Adjunctive Quetiapine Versus Adjunctive Haloperidol in Combination with Sodium Valproate for Treatment of Patients with Mania or Mixed Feature Bipolar I Disorder: A Randomized Double-Blind Clinical Trial Study

Mercedeh Samiei,

Zahra Sepehrifar,

Reza Daneshmand,

Gita Sadighi

Samiei M, Sepehrifar Z, Daneshmand R, Sadighi G. Comparison of Adjunctive Quetiapine Versus Adjunctive Haloperidol in Combination with Sodium Valproate for Treatment of Patients with Mania or Mixed Feature Bipolar I Disorder: A Randomized Double-Blind Clinical Trial Study. Iran J Psychiatry Behav Sci. 2021;15(2):e90106. doi: https://doi.org/10.5812/ijpbs.90106

22

Jan

2014

The Comparison of the Effectiveness of Thiothixene and Risperidone as a Combination with Lithium for the Treatm ent of Patients with Bipolar Disorder

Shahrzad Mazhari,

Hasan Ziaadini,

Nooshin Parvaresh,

Maryam Fazli

Mazhari S, Ziaadini H, Parvaresh N, Fazli M. The Comparison of the Effectiveness of Thiothixene and Risperidone as a Combination with Lithium for the Treatm ent of Patients with Bipolar Disorder. Zahedan J Res Med Sci. 2014;16(10(suppl)):. doi:

24

Sep

2006

Sodium Valproate effect in occurrence of Polycystic Ovarian Syndrome

Behnaz Behnam,

Afshin Samaei,

Raheb Ghorbani,

Mandana Rashidi,

Taibe MirAkhorlo

Behnam B, Samaei A, Ghorbani R, Rashidi M, MirAkhorlo T. Sodium Valproate effect in occurrence of Polycystic Ovarian Syndrome. koomesh. 2006;8(1):e152113. doi:

30

Jul

2007

Add-on Topiramate for the Pharmacological Management of Schizophrenia: A Double Blind Randomized Clinical Trial

Seyed Ghafur Mousavi,

Sharareh Golchin,

Hamid Afshar,

Hamid Reza Rooh Afza

Mousavi SG, Golchin S, Afshar H, Rooh Afza HR. Add-on Topiramate for the Pharmacological Management of Schizophrenia: A Double Blind Randomized Clinical Trial. Iran J Psychiatry Behav Sci. 2007;1(2):. doi:

26

Jan

2026

Effects of Clozapine Add-On to Risperidone vs. Risperidone Monotherapy on Agitation in Paranoid Schizophrenia: A Quasi-experimental Pilot Study

Najmiatul Fitria,

Hidayatul Arief,

Yelly Oktavia Sari,

Syofyan Syofyan

Fitria N, Arief H, Oktavia Sari Y, Syofyan S. Effects of Clozapine Add-On to Risperidone vs. Risperidone Monotherapy on Agitation in Paranoid Schizophrenia: A Quasi-experimental Pilot Study. Iran J Psychiatry Behav Sci. 2026;20(1):e164189. doi: https://doi.org/10.5812/ijpbs-164189

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Author(s):

Victoria Omranifard:[PubMed][Scholar]
Afsaneh Karbasi Amel:[PubMed][Scholar]
Siamak Amanat:[PubMed][Scholar]

IJPBS is the Official Journal of Mazandaran University of Medical Sciences

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Sodium Valproate as an Adjunctive Drug in Treatment of Schizophrenia

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