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IJ Psychiatry and Behavioral Sciences
IJPBS is the Official Journal of Mazandaran University of Medical Sciences
e-ISSN 1735-9287
p-ISSN 1735-8639
Image Credit:Iran J Psychiatry Behav Sci
Outline
Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania
Authors
1Resident, Razi Psychiatric Hospital, Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
2Psychiatrist, Associate Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
3Clinical Psychologist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
4Psychiatrist, Assistant Professor, Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
*Corresponding Author: Resident, Razi Psychiatric Hospital, Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran, Tel: +98-2133401604, Fax: +98-2133401604 Email: zahesbanoo@yahoo.com
Published online:Dec 30, 2013
Article type:Research Article
Received:Feb 28, 2013
Accepted:Sep 19, 2013
How to Cite:Mirsepassi Z, Mazinani R, Fadai F, Alibeigi N, Nazeri-Astaneh A. Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania. Iran J Psychiatry Behav Sci. 2013;7(2):. doi:
Abstract
Objective: The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania.
Methods: In this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by Young Mania Rating Scale (YMRS) weekly.
Results: In both intervention and control groups, YMRS score had significant decline after 8 weeks (p < 0.001), but there was no statistically significant difference between the two groups (p = 0.419). The highest score decline was after two weeks. YMRS score at baseline did not have statistically significant difference between the intervention and control groups (p = 0.709).
Conclusions: This study failed to show antimanic efficacy of adjunctive topiramate in the treatment of those with acute manic.
Declaration of interest: None. Clinical Trial Registration: URL: http://www.irct.ir. IRCT201110317960N1.
Citation: Mirsepassi Z, Mazinani R, Fadai F, Alibeigi N, Nazeri-Astaneh A. Topiramate add-on lithium carbonate for treatment of acute mania. Iran J Psychiatry Behav Sci 2013; 7(2): 11-5
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References
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Copyright
© 2013, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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