IJ Radiology
Hasan Aydin1, Nilay Aydin Oktay1, Volkan Kizilgoz1,*, Elif Altin Altin1, Idil Gunes Tatar1, 
Baki Hekimoglu2Epilepsy, a well-known mostly idiopathic neurologic disorder, has to be correctly diagnosed and properly treated. Up to now, several diagnostic approaches have been processed to determine the epileptic focus.
The aim of this study was to discover whether proton-MR-spectroscopic imaging (MRSI) aids in the diagnosis of temporal lobe epilepsy in conjunction with classical electroencephalography (EEG) findings.
Totally, 70 mesial temporal zones consisting of 39 right hippocampi and 31 left hippocampi of 46 patients (25 male, 21 female) were analyzed by proton MRSI. All patients underwent a clinical neurologic examination, scalp EEG recording and prolonged video EEG monitoring. Partial seizures on the right, left or both sides were recorded in all patients. All patients were under medical treatment and none of the patients underwent amygdalohippocampectomy and similar surgical procedures.
The normal average lactate (Lac), phosphocreatine, N-acetyl aspartate (NAA), creatine (Cr), choline (Cho), myo-inositol, glutamate and glutamine (Glx) peaks and Nacetyl aspartate/Cr, NAA/ Cho + Cr, Cho/Cr ratios were measured from the healthy opposite hippocampi or from the control subjects. The Lac, glutamate and glutamine (Glx), myo-inositol, phosphocreatine and NAA metabolites plus Cho/Cr ratio showed statistical difference between the normal and the epileptic hippocampi. Cho, Cr metabolites plus NAA/Cr, NAA/ Cho + Cr ratios were almost the same between the groups. The sensitivity of Proton-MR-Spectroscopy for lateralization of the epileptic foci in all patients was 96% and the specificity was 50%.
Proton-MRSI can easily be considered as an alternative modality of choice in the diagnosis of temporal lobe epilepsy and in the future; Proton-MR-Spectroscopy may become the most important technique used in epilepsy centers.
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Raminfard S, Haghighatkhah H, Alimohamadi M, Yoonessi A, Arbabi F, et al. Assessment of Residual Tumor After Resection of Glioma: A Magnetic Resonance Spectroscopic Study. Arch Neurosci. 2019;6(Brain Mapping):e88159. doi: https://doi.org/10.5812/ans.88159
Taheri H, Elahifar MA, Bighamian A. Magnetic Resonance Spectroscopy in Neurological Disorders. I J Radiol. 2014;11(30th Iranian Congress of Radiology):e21326. doi: https://doi.org/10.5812/iranjradiol.21326
Farzadniya A, Mehvari J, Basiratnia R, Mehrabi F. Comparison of Blood Perfusion Parameters in the Ipsilateral and Contralateral Sides of the Brain in Known Cases of Mesial Temporal Lobe Epilepsy. I J Radiol. 2021;18(2):e107887. doi: https://doi.org/10.5812/iranjradiol.107887
Tari E, Heidari M, Badv RS, Zamani F. The Agreement Between Long-Term Monitoring by Electroencephalography and Magnetic Resonance Imaging in Paediatric Seizure. Inn J Pediatr. 2023;33(6):e138279. doi: https://doi.org/10.5812/ijp-138279
Rahimian N, Saligheh Rad H, Firouznia K, Ebrahimzadeh SA, Meysamie A, et al. Magnetic Resonance Spectroscopic Findings of Chronic Lesions in Two Subtypes of Multiple Sclerosis: Primary Progressive Versus Relapsing Remitting. I J Radiol. 2013;10(3):128-132. doi: https://doi.org/10.5812/iranjradiol.11336
Checking
Last Update: 2 weeks ago
Last Update: 2 weeks ago
Last Update: 2 weeks ago
Last Update: 4 days ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):
