IJ Radiology
Endothelial injury is a well-known complication in chronic kidney disease (CKD) and hemodialysis. One of the sites in which early vascular changes may be detected is the retina. Of course, these flow changes may not be detected in ophthalmologic exams, but it seems that color Doppler sonography of retinal arteries may be helpful in these cases.
In previous studies on CKD patients who underwent chronic hemodialysis, hemodynamic changes were noted in retinal arteries, but no study has been performed to determine which of the two processes (CKD or chronic hemodialysis) can produce these changes. In this study, we tried to answer this question.
Doppler ultrasonography of the orbital vasculature including the ophthalmic artery and the central retinal artery was carried out in 17 patients (34 eyes) with chronic renal failure (CRF) who underwent hemodialysis, 17 patients (34 eyes) with CRF without a history of hemodialysis and 17 normal patients (34 eyes). The peak systolic velocity (PSV), end diastolic velocity (EDV) and resistance index were measured excluding hypertensive, diabetic patients and patients with cardiovascular disease.
The mean PSV and EDV were lower only in the ophthalmic artery of CRF patients irrespective of the history of hemodialysis (PSV was 35.2 in hemodialysis, 38.8 in CRF and 51.6 in normal patients, P value = 0.001 and EDV was 7.4, 9.4, 11.8, respectively, P value = 0.001) with no significant difference in the resistance index of the ophthalmic artery and other parameters [EDV, PSV, Resistance Index (RI)] in the central retinal artery.
The mean PSV and DSV in the ophthalmic artery were lower only in the ophthalmic artery of CRF patients regardless of the history of hemodialysis. No significant difference in the resistance index of the ophthalmic artery and other parameters (EDV, PSV) of the central retinal artery were noted between different groups. These findings suggest that microvascular disease and endothelial cell dysfunction of the orbital vasculature are related to CRF and not to chronic hemodialysis.
© 2012, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Dighe T, Kalekar T, Kuber R, Saha D, Shinde N, et al. A Cross-Sectional Study to Evaluate Diffusion Tensor Imaging Findings of the Brain in End-Stage Renal Disease (ESRD) Patients Undergoing Maintenance Hemodialysis Using Volume of Interest Method. Nephro-Urol Mon. 2024;16(1):e143378. doi: https://doi.org/10.5812/numonthly-143378
Bonomini M, Pandolfi A, Sirolli V, Arduini A, Liberato LD, et al. Erythrocyte Alterations and Increased Cardiovascular Risk in Chronic Renal Failure. Nephro-Urol Mon. 2017;9(3):e45866. doi: https://doi.org/10.5812/numonthly.45866
Mazarei M. Retinal complications in essential hypertension at first eye examination in Bou-Ali Medical Center. J Inflamm Dis. 2024;4(3):e154722. doi:
Feng Y, Wang J, Chen L. Hemodynamic Changes in the Ophthalmic Artery and Their Correlation with Serum Cytokines in Pediatric Diabetic Retinopathy. Inn J Pediatr. 2026;36(3):e163976. doi: https://doi.org/10.5812/ijp-163976
Besharaty M, Rastegar A, Shoja M, Emami M. The prevalence of hypertensive retinopathy in referral patients to hospitals of Yazd. J Inflamm Dis. 2024;8(4):e155101. doi:
Checking
Last Update: 2 weeks ago
Last Update: 2 weeks ago
Last Update: 2 weeks ago
Last Update: 4 days ago
Ordering Reprints
Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC
Author(s):
