QCT and Diagnosis of Osteoporosis

How to Cite:Ebrahimpour L. QCT and Diagnosis of Osteoporosis. I J Radiol. 2014;11(30th Iranian Congress of Radiology):e21298. doi: https://doi.org/10.5812/iranjradiol.21298

Abstract

Noninvasive measurement of bone mineral density (BMD) is a technology that benefits both the patient and society through its potential to decrease the morbidity, mortality, and cost of fractures associated with osteoporosis through early detection and treatment. In general, two sites are assessed, the spine and the hip. If one of these sites cannot be assessed, the protocol should outline the next site to be used. Quantitative computed tomography (QCT) can identify patients with low BMD compared to the QCT reference database and who are at risk for fracture. QCT cannot be used to diagnose osteoporosis based on the quantitative BMD value obtained, since it has never been validated for WHO criteria. It is, however, the only other technology besides DXA that is approved for treatment follow up. Quantitative computed tomography (CT) is a three-dimensional non-projectional technique to quantify bone mineral density (BMD) in the spine, proximal femur, forearm, and tibia with a number of advantages to other densitometric techniques: cortical and trabecular bone can be separated, trabecular volumes of interest (VOI) are largely independent of degenerative changes in the spine; so, QCT can be used to assess/monitor patients with extensive degenerative disc disease, more sensitively than DXA for density changes in the vertebral body and 3D geometric parameters can be determined. Bone mineral density (BMD), as measured by QCT, is a true density measured in g/cm3, in contrast to dual-energy X-ray absorptiometry (DXA), which determines an areal density (BMDa) measured in g/cm2. It has also some disadvantages such as higher radiation dose and lack of applicability with WHO diagnostic criteria, Furthermore, diagnosis of low bone mass is made by using the QCT criteria which is technically more difficult than DXA unless spiral technique is used. In modern spiral CT scanners, various techniques are implemented to significantly reduce radiation exposure by optimally adapting the X-ray tube current to the individual subject being scanned. The level of dose reduction depends on anatomical location. However, due to limited medical evidence, definitive advice on its use in all clinical practices cannot be provided until more data emerge.

Full Text

Full text is available in PDF

CT-Scan as an Opportunistic Osteoporosis Screening Tool in High-Risk Populations; A Diagnostic Study Conducted on a Sample of Urinary Stone Patients

Mohammad Ali Ganji Jameshouran,

Amir Reza Abedi,

Saeed Montazeri,

Mohammad Ali Tasharrofi,

Mohammad Mersad Mansouri Tehrani

Ganji Jameshouran MA, Abedi AR, Montazeri S, Tasharrofi MA, Mansouri Tehrani MM. CT-Scan as an Opportunistic Osteoporosis Screening Tool in High-Risk Populations; A Diagnostic Study Conducted on a Sample of Urinary Stone Patients. I J Radiol. 2020;17(4):e102177. doi: https://doi.org/10.5812/iranjradiol.102177

7

Oct

2025

Comparison of CT Scan and Bone Mineral Densitometry for Diagnosing Osteoporosis and Osteopenia in Patients with Chronic Kidney Disease

Sedigheh Ghorbaniafzal,

Zohreh Rostami,

Mehdi Raei,

Mohammad Javanbakht,

Ramezan Jafari,

Effat Naeimi

,et al.

Ghorbaniafzal S, Rostami Z, Raei M, Javanbakht M, Jafari R, et al. Comparison of CT Scan and Bone Mineral Densitometry for Diagnosing Osteoporosis and Osteopenia in Patients with Chronic Kidney Disease. Nephro-Urol Mon. 2025;17(4):e161015. doi: https://doi.org/10.5812/numonthly-161015

17

Jul

2023

Diagnostic Value of Trabecular Bone Score in Osteoporosis

Alireza Rajaei,

Khatereh Mohammadi,

Mahbobeh Oroei,

Faraneh Farsad

Rajaei A, Mohammadi K, Oroei M, Farsad F. Diagnostic Value of Trabecular Bone Score in Osteoporosis. I J Radiol. 2023;20(2):e131845. doi: https://doi.org/10.5812/iranjradiol-131845

27

Jan

2016

Correlating Whole-Body Bone Mineral Densitometry Measurements to Those From Local Anatomical Sites

Alireza Rajaei,

Pooneh Dehghan,

Saideh Ariannia,

Arman Ahmadzadeh,

Madjid Shakiba,

Kourosh Sheibani

Rajaei A, Dehghan P, Ariannia S, Ahmadzadeh A, Shakiba M, et al. Correlating Whole-Body Bone Mineral Densitometry Measurements to Those From Local Anatomical Sites. I J Radiol. 2016;13(1):e25609. doi: https://doi.org/10.5812/iranjradiol.25609

24

Aug

2021

Assessment of Bone Density of Patients Referred to Arak Densitometry Center from 2016 to 2017: A Cross-sectional Study

Hossein Malekee,

Mohsen Tabatabaei,

Baharak Tasorian

Malekee H, Tabatabaei M, Tasorian B. Assessment of Bone Density of Patients Referred to Arak Densitometry Center from 2016 to 2017: A Cross-sectional Study. Jundishapur J Chronic Dis Care. 2021;10(4):e112744. doi: https://doi.org/10.5812/jjcdc.112744

Import into EndNote Import into BibTex

Crossmark

Checking

Share on

Comments

Number of Comments:0

Cited by

Scopus by DOI: 0
Last Update: 6 days ago
Scopus by Title: 0
Last Update: 6 days ago
Scopus by Title (Ref): 0
Last Update: 6 days ago
CrossRef: 0
Last Update: 3 days ago

Metrics

Licensing and reuse information

Ordering Reprints

Articles are published under the Creative Commons license stated on each article. No permission or royalty fee is required for uses permitted by that license. CCC handles optional bulk and customized reprint orders. Any quotation covers production and delivery services only, not copyright permission. > Request Reprints from CCC

Search Relations

Author(s):

Laleh Ebrahimpour:[PubMed][Scholar]

An Innovative Journal in the Field of Radiology

Outlines

QCT and Diagnosis of Osteoporosis

Abstract

Full Text

Similar Articles

CT-Scan as an Opportunistic Osteoporosis Screening Tool in High-Risk Populations; A Diagnostic Study Conducted on a Sample of Urinary Stone Patients

Comparison of CT Scan and Bone Mineral Densitometry for Diagnosing Osteoporosis and Osteopenia in Patients with Chronic Kidney Disease

Diagnostic Value of Trabecular Bone Score in Osteoporosis

Correlating Whole-Body Bone Mineral Densitometry Measurements to Those From Local Anatomical Sites

Assessment of Bone Density of Patients Referred to Arak Densitometry Center from 2016 to 2017: A Cross-sectional Study

Crossmark

Checking

Last Update: 6 days ago

Last Update: 6 days ago

Last Update: 6 days ago

Last Update: 3 days ago