Full Text
Full text is available in PDF
Objectives:
To assess the diagnostic accuracy of PET-MRI and MRI alone for the detection of local recurrences of soft tissue sarcomas (STS) after initial surgical resection of the primary tumors.
An Innovative Journal in the Field of Radiology
e-ISSN 2008-2711
p-ISSN 1735-1065
Comparing the Diagnostic Performance of Integrated 18F-FDG PET-MRI and MRI for the Identification of Local Recurrences of Soft Tissue Sarcomas
Authors
1University Hospital Essen, Germany
*Corresponding Author: University Hospital Essen, Germany, Youssef.Erfanian@uk-essen.de. Email: Youssef.Erfanian@uk-essen.de
Published online:Apr 12, 2017
Article type:Abstract
Received:Dec 20, 2016
Accepted:Feb 07, 2017
How to Cite:Erfanian Y, Gruneisen J, Podleska L, Poeppe T, Umutlu L. Comparing the Diagnostic Performance of Integrated 18F-FDG PET-MRI and MRI for the Identification of Local Recurrences of Soft Tissue Sarcomas. I J Radiol. 2017;14(Special Issue):e47962. doi: https://doi.org/10.5812/iranjradiol.47962
Abstract
Methods:
A total of 41 patients with a clinically suspected tumor relapse of STS underwent an 18F-FDG- PET-MRI examination for assessment of local recurrence. Two experienced physicians interpreted the MRI data and subsequently the PET-MRI datasets in two separate reading sessions and were instructed to identify potential local tumor recurrences. Additionally, the diagnostic confidence in each reading for the identification of malignant lesions was determined. A McNemar test was applied to test for differences of both ratings and a Wilcoxon signed-rank test was used to identify differences of the confidence levels. Histopathological verification as well as follow-up imaging was applied as the standard of reference.
Results:
A tumor relapse was present in 27 / 41 patients. Calculated sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accurary for the detection of local tumor recurrence was 81%, 85%, 91%, 70%, 82% for MRI and 96%, 75%, 89%, 91%, 90% for PET-MRI (P > 0.05). Furthermore, PET/MRI showed significantly higher confidence levels (P < 0.05) for the determination of malignant lesions.
Conclusions:
Our results demonstrate 18F-FDG PET-MRI to be an excellent imaging method in the evaluation of recurrent STS after surgical excision, as it displays superior detection accuracy as compared to routine MRI follow-up examinations.
Highlights
Copyright
© 2017, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
12
Apr
2017
The Role of 18F FDG PET/CT in Clinical Management of Breast Cancer; Additional Value Over Conventional Imaging Modalities
Mehrdad Bakhshayeshkaram,
Farahnaz Aghahosseini,
Abtin Doroudinia
Bakhshayeshkaram M, Aghahosseini F, Doroudinia A. The Role of 18F FDG PET/CT in Clinical Management of Breast Cancer; Additional Value Over Conventional Imaging Modalities. I J Radiol. 2017;14(Special Issue):e47975. doi: https://doi.org/10.5812/iranjradiol.47975
20
Jun
2016
Pattern of Recurrence of Myxofibrosarcoma is not Associated with Pattern at Presentation or Rate of Delayed Diagnosis
Corey Daniels,
Wei-Lien Wang,
John Edward Madewell,
Wei Wei,
Behrang Amini
Daniels C, Wang W, Madewell JE, Wei W, Amini B. Pattern of Recurrence of Myxofibrosarcoma is not Associated with Pattern at Presentation or Rate of Delayed Diagnosis. I J Radiol. 2017;14(1):e13469. doi: https://doi.org/10.5812/iranjradiol.32548
1
Dec
2018
Impact of FDG-PET and Dynamic Contrast-Enhanced MRI in Comparison with DWI for N-Staging in Lung Cancer Patients
Paul Flechsig,
Heike Zabeck,
Sebastian Reubold,
Christos Sachpekidis,
Hendrik Rathke,
Manuel R&ouml;hrich
,et al.Flechsig P, Zabeck H, Reubold S, Sachpekidis C, Rathke H, et al. Impact of FDG-PET and Dynamic Contrast-Enhanced MRI in Comparison with DWI for N-Staging in Lung Cancer Patients. I J Radiol. 2019;16(1):e68638. doi: https://doi.org/10.5812/iranjradiol.68638
30
Mar
2013
The Validity of MRI in Evaluation of Tumor Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer
M Abedi,
D Farrokh,
Fatemeh Homaei Shandiz,
A Joulaee,
R Anbiaee,
B Zandi
,et al.Abedi M, Farrokh D, Homaei Shandiz F, Joulaee A, Anbiaee R, et al. The Validity of MRI in Evaluation of Tumor Response to Neoadjuvant Chemotherapy in Locally Advanced Breast Cancer. Int J Cancer Manag. 2013;6(1):e80382. doi:
10
Jan
2016
Role of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Evaluation of Cytologically Indeterminate Thyroid Nodules
Gulgun Buyukdereli,
Yasemin Aktar,
Ertan Kara,
Aysun Uguz,
Husnu Sonmez
Buyukdereli G, Aktar Y, Kara E, Uguz A, Sonmez H. Role of 18F-fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in the Evaluation of Cytologically Indeterminate Thyroid Nodules. I J Radiol. 2016;13(1):e21186. doi: https://doi.org/10.5812/iranjradiol.21186
Cited by
- Scopus by DOI: 0
Last Update: 1 week ago
- Scopus by Title: 0
Last Update: 1 week ago
- Scopus by Title (Ref): 0
Last Update: 1 week ago
- CrossRef: 0
Last Update: 6 days ago
- OpenAlex: 0
Last Update: 2 days ago
- OpenCitations: 0
Last Update: 3 days ago
Comments
Number of Comments:0