IJ Radiology
Due to the impact of threats on the clinical outcome and survival of the lung-heart transplant recipients, such as invasive pulmonary Aspergillosis, we aimed to compare the high resolution computed tomography (HRCT) scan findings with the serum BAL galactomannan and fungal culture in these patients.
We reviewed the data of lung-heart transplant recipients within a 5 year period at our center. The inclusion criterion was confirmed invasive pulmonary Aspergillosis. Demographic, clinical, radiologic and laboratory characteristics of the patients were retrieved from their files and reported.
We reviewed the data of 30 patients (mean age = 36.1 13.3; Male gender = 22 (73.3%). Seventeen patients (56.7%) patients had double lung transplant, 10 933.3% had single lung transplant and 3 (10%) had heart-lung transplant. Consolidation was the most observed finding in the HRCT (n = 25) ([83.3%]) and it was more present in the left lower lobe of the lung. Ground glass opacity was observed in 19 (63.3%) of the patients and mostly in the left lower lobe. Pleural thickening and pleural effusion were present in 7 (23.3) and 19 (63.3%) of the patients, respectively. Small-size nodular infiltration (< 5 mm) was present in 19 (63.3%) while large-size nodular infiltration (> 5 mm) was observed in only 5 (16.7%) patients. Twenty-seven (90%) patients had positive culture results, while serum and bronchoalveolar lavage galactomannan was positive in 5 (16.7) and 9 (30%) patients, respectively. Four (13.3%) patients died during the study period. However, there was no association between the HRCT and laboratory characteristics of the study population.
HRCT is helpful in the diagnosis of invasive pulmonary aspergillosis in patients with lung-heart transplant.
© 2017, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Kahkouee S, Kouchebaghi D, Karimi MA. HRCT Features of Pulmonary Aspergillosis in Patients With Solid Organ Transplant. I J Radiol. 2014;11(30th Iranian Congress of Radiology):e21268. doi: https://doi.org/10.5812/iranjradiol.21268
Farshchian N, Vaziri S. Evaluating Diagnostic Role of High Resolution Computerized Tomography in Active Pulmonary Tuberculosis. J Kermanshah Univ Med Sci. 2005;9(1):e81514. doi:
Uppal MR, Uppal R, Saeed U, Uppal MS, Rizwan Uppal S, et al. Revolutionizing Tuberculosis Detection: High-resolution CT as a Game-Changer in Public Health Surveillance and Early Case Finding. Compr Health Biomed Stud. 2025;4(1):e163885. doi: https://doi.org/10.5812/chbs-163885
Kahkouee S, Mami F, Karimi MA. Comparison of HRCT Features of Pneumocystis Jiroveci Pneumonia in Patients With and Without HIV. I J Radiol. 2014;11(30th Iranian Congress of Radiology):e21267. doi: https://doi.org/10.5812/iranjradiol.21267
Zarrinfar H, Mirhendi H, Fata A, Khodadadi H, Kordbacheh P. Detection of Aspergillus flavus and A. fumigatus in Bronchoalveolar Lavage Specimens of Hematopoietic Stem Cell Transplants and Hematological Malignancies Patients by Real-Time PCR, Nested Polymerase Chain Reaction and Mycological Assays. Jundishapur J Microbiol. 2015;8(1):e13744. doi: https://doi.org/10.5812/jjm.13744
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