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International Cardiovascular Research Journal
An annual journal in scientific affiliation with the Cardiovascular Research Center, Shiraz University of Medical Sciences
e-ISSN 2251-9149
p-ISSN 2251-9130
Image Credit:Int Cardiovasc Res J
Outline
Angiotensin Converting Enzyme Gene I/D Polymorphism in Pakistani Rheumatic Heart Disease Patients and Healthy Controls
Authors
1Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan
2Shifa College of Medicine, Shifa Tameer-e-Millat University, Islamabad, Pakistan
3Armed Forces Institute of Cardiology and National Institute of Heart diseases, Rawalpindi, Pakistan
4Pir Mehr Ali Shah Arid Agriculture University, Rawlpindi, Pakistan
*Corresponding Author: Corresponding author: Sadia Rehman, Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan Email: sadiawasiq@gmail.com
Published online:Sep 30, 2017
Article type:Research Article
Received:Feb 28, 2017
Accepted:Apr 08, 2015
How to Cite:Rehman S, Saba N, Akhtar N, Munir S, Ahmed W, et al. Angiotensin Converting Enzyme Gene I/D Polymorphism in Pakistani Rheumatic Heart Disease Patients and Healthy Controls. Int Cardiovasc Res J. 2017;9(3):e11238. doi:
Abstract
Background: Valve scarring and collagen deposition are crucial in pathogenesis of Rheumatic Heart Disease (RHD), an autoimmune disorder of the heart. Angiotensin I-Converting Enzyme (ACE) plays a major role in fibrous tissue formation.
Objectives: The present research work aimed to assess the role of ACE Insertion/Deletion (I/D) polymorphism in progress of RHD.
Patients and Methods: DNA was pre pared from blood samples from 156 RHD patients (156) and 204 healthy ethnically-matched controls. Then, it was screened using sequence-specific Primers. Polymerase chain reaction and Agarose gel electrophoresis. The data were analyzed using Vassar stats (http://faculty.vassar.edu/lowry/VassarStats.html).
Results: I allele (P = 0.024, OR = 1.42) and II genotype (P = 0.001, OR = 3.07) were significantly higher in Pakistani RHD patients compared to the healthy controls. Also, a significant difference was found between the female, but not male, patients and the controls regarding I allele and II genotype.
Conclusions: The study results provided information about involvement of ACE I/D polymorphism in molecular mechanism of RHD. Thus, it can become one of the useful tools in risk assessment and help with designing strategies to combat the disease.
Highlights
References
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Copyright
© 2017, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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