Journal of Cellular & Molecular Anesthesia
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Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Can Alleviate the Proctitis Model Through TLR4/NF-Kb Pathway
Zahra Ebrahim Soltani1,*, Mohammad Elahi2, Hasti Tashak-Golroudbari3, Abolfazl Badripour 3, Hojjatollah Nazari 4, Asieh Heirani-Tabasi1, Reza Akbari Asbagh 3, Mohammad Amin Dabbagh Ohadi 3, Moojan Shabani 3, Mina Mahboudi3, Mojdeh Sarzaeim 3, alireza mahdavi2, Behnam Behboudi5, Mohammad Reza Keramati5, Alireza Kazemeini5, Seyed Mohsen Ahmadi Tafti6Abstract
Background: Proctitis is a significant concern of inflammatory bowel diseases, especially ulcerative colitis. Exosomes are a new method for treating many diseases by their immunosuppressive and tissue-repairing potential. Here, we tried Mesenchymal stem cells (MSCs)-derived Exosomes for treating the proctitis model of rats. Materials and Methods: Rats were assigned into four groups: sham, control group, rectal, and intraperitoneal exosome injection. The proctitis model was induced by rectal administration of 4% acetic acid. The exosome was derived from human MSCs isolated from human umbilical cords. After seven days, rectum samples were assessed for histopathological, IHC, and PCR analysis. Results: The histopathologic scores, collagen deposition, and the expression of NF-?B, TLR4, TNF?, IL-6, and TGF? were decreased in intraperitoneal exosome compared to controls. The result was not promising for the rectal administration of exosomes. Conclusion: Exosomes can suppress the inflammatory response in the proctitis model and improve the rectum's healing process. Exosomes can inhabit the NF-?B/TLR4 pathway and downstream pro-inflammatory cytokines. This study implicates the therapeutic benefits of exomes in treating proctitis.
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© 2023, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
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Author(s):
- Zahra Ebrahim Soltani:[PubMed][Scholar]
- Mohammad Elahi:[PubMed][Scholar]
- Hasti Tashak-Golroudbari:[PubMed][Scholar]
- Abolfazl Badripour :[PubMed][Scholar]
- Hojjatollah Nazari :[PubMed][Scholar]
- Asieh Heirani-Tabasi:[PubMed][Scholar]
- Reza Akbari Asbagh :[PubMed][Scholar]
- Mohammad Amin Dabbagh Ohadi :[PubMed][Scholar]
- Moojan Shabani :[PubMed][Scholar]
- Mina Mahboudi:[PubMed][Scholar]
- Mojdeh Sarzaeim :[PubMed][Scholar]
- alireza mahdavi:[PubMed][Scholar]
- Behnam Behboudi:[PubMed][Scholar]
- Mohammad Reza Keramati:[PubMed][Scholar]
- Alireza Kazemeini:[PubMed][Scholar]
- Seyed Mohsen Ahmadi Tafti:[PubMed][Scholar]