Methicillin Resistant Staphylococcus aureus in Children

Samileh Noorbakhsh; Ahmad Siadati; Mohammad Farhadi; of Medical Sciences; Shahnaz Rimaz; Azardokht Tabatabaei

Journal of Comprehensive Pediatrics

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Methicillin Resistant Staphylococcus aureus in Children

Author(s):

Samileh Noorbakhsh^1,*,

Ahmad Siadati²,

Mohammad Farhadi³,

of Medical Sciences Tehran ³,

Shahnaz Rimaz⁴,

Azardokht Tabatabaei²

1Research Center of Pediatrics Infectious Diseases, Iran University of Medical Sciences, [email protected], IR Iran

2Department of Pediatrics, Tehran University of Medical Sciences, IR Iran

3Research Center of Ear and Neck Surgery, Iran University

4Department of Public Health, Iran University of Medical Sciences, Iran

Journal of Comprehensive Pediatrics:Vol. 1, issue 1; 24-30

Published online:Jun 30, 2007

Article type:Research Article

Received:Jan 01, 2007

Accepted:Jan 01, 2007

How to Cite:Noorbakhsh S, Siadati A, Farhadi M, OMS, Rimaz S, et al. Methicillin Resistant Staphylococcus aureus in Children. J Compr Ped. 2007;1(1):. doi:

Abstract

Background:The changing epidemiology of Methicillin Resistant Staphylococcus aureus (MRSA) became evident in the 1990s when community- acquired MRSA cases were first reported. Increasing prevalence of MRSA will inevitably increase the use of vancomycin, adding further to the problem of antimicrobial resistance.
The previous retrospective study during 1996-1998 in Rasool Akram Hospital determined the increasing prevalence of MRSA. The goal of this prospective descriptive study was to determine the antibiotic resistance pattern of Staphylococci spp responsible for upper respiratory infections in children.
Materials and Methods: From Dec 2001 to Dec 2003, we surveyed 73 Staphylococci spp (78.1%, S. aureus, 21.9% coagulase negative) obtained from children (1 month- 14 yrs) with upper respiratory infections (otitis media; mastoiditis; sinusitis; tracheitis,…). All isolates (blood; CSF or other sterile body fluids) after culturing and antibiogram were first evaluated by disc diffusion and then by Etesting for MIC detection.
Results: The results showed an increasing resistance to penicillin (100% vs 70%); and gentamicin (56.3% vs 30%); and a decreased resistance to erythromycin (47% vs 66%); oxacillin (11.6% vs 40%); and chloramphenicol (15.4% vs 22%). Only 6.8% of S.aureus and 25% of coagulase negative staph are MRSA.
MRSA prevalence in this study is 6.4% similar to the previous study (5.4%) and there has been no significant increase during 4 years. By using penicillinase inhibitor or other non beta lactam antibiotics more than 80% antibiotic coverage will be achieved. In a minority of cases (6.8%) vancomycin was needed.
Conclusion: We conclude that the prevalence of MRSA is rare in the present study. Therefore, vancomycin is not efficient for the empiric therapy of all Staphylococcal suspected infections. Penicillin is not appropriate for the treatment of children with suspected Staphylococcal infections. PRP plus one of the gentamicin; rifampin; clindamycin; chloramphenicol or Trimethoprim/ Sulfamethoxazole are recommended in severe cases. When staphylococci may be involved in more extensive infections, the empirical use of clindamycin provides appropriate coverage including the majority of community- acquired MRSA strains. Limiting broad spectrum antibiotic use will minimize the antibiotic pressure that favors selection of resistant strains. In severe, invasive staphylococcal infections, such as severe pneumonia or toxic shock syndrome, inclusion of vancomycin in an empiric antibiotic regimen may be prudent initially, particularly among children with predisposing risk factors for MRSA carriage.

Keywords

MRSA (Methicillin Resistant Staphylococcus aureus)

Antibiotic resistant

Staphylococcal infection

Upper respiratory infections

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Methicillin-Resistant Staphylococcus aureus Isolated From Various Types of Hospital Infections in Pediatrics: Panton-Valentine Leukocidin, Staphylococcal Chromosomal Cassette mec SCCmec Phenotypes and Antibiotic Resistance Properties

Banafshe Dormanesh,

Soheila Siroosbakhat,

Ebrahim Khodaverdi Darian,

Ladan Afsharkhas

Dormanesh B, Siroosbakhat S, Khodaverdi Darian E, Afsharkhas L. Methicillin-Resistant Staphylococcus aureus Isolated From Various Types of Hospital Infections in Pediatrics: Panton-Valentine Leukocidin, Staphylococcal Chromosomal Cassette mec SCCmec Phenotypes and Antibiotic Resistance Properties. Jundishapur J Microbiol. 2015;8(11):e11341. doi: https://doi.org/10.5812/jjm.11341

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2011

Nasal Carriage Rate of Community- and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus in Children, Kermanshah, Iran

Ghadiri K,

Ebrahimi E,

Akramipour R

K G, E E, R A. Nasal Carriage Rate of Community- and Hospital-Acquired Methicillin-Resistant Staphylococcus aureus in Children, Kermanshah, Iran. Arch Clin Infect Dis. 2011;6(3):. doi:

2

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2013

Vancomycin and Linezolid Resistant Staphylococcus in Hospitalized Children

Shahnaz Armin,

Alaleh Rouhipour,

Fatemeh Fallah,

Mohammad Rahbar,

Mohammad Ebrahimi

Armin S, Rouhipour A, Fallah F, Rahbar M, Ebrahimi M. Vancomycin and Linezolid Resistant Staphylococcus in Hospitalized Children. Arch Pediatr Infect Dis. 2013;1(1):. doi: https://doi.org/10.5812/pedinfect.5190

1

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2014

Risk Factors for Methicillin Resistant Staphylococcus aureus Nasal Colonization of Healthy Children

Babak Soltani,

Abbas Taghavi Ardakani,

Alireza Moravveji,

Mahzad Erami,

Mostafa Haji Rezaei,

Rezvan Moniri

,et al.

Soltani B, Taghavi Ardakani A, Moravveji A, Erami M, Haji Rezaei M, et al. Risk Factors for Methicillin Resistant Staphylococcus aureus Nasal Colonization of Healthy Children. Jundishapur J Microbiol. 2014;7(9):e20025. doi: https://doi.org/10.5812/jjm.20025

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2023

Clinical Characteristics and Microbial Profiles of Paediatric Patients with Methicillin-Resistant Staphylococcus aureus Pneumonia in China

Shu Li Wang,

Jun Lin Wang,

Shu Hong Sun,

Hua Tao,

Li Wang,

Xing Long Wu

,et al.

Wang SL, Wang JL, Sun SH, Tao H, Wang L, et al. Clinical Characteristics and Microbial Profiles of Paediatric Patients with Methicillin-Resistant Staphylococcus aureus Pneumonia in China. Jundishapur J Microbiol. 2022;15(11):e132894. doi: https://doi.org/10.5812/jjm-132894

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Author(s):

Samileh Noorbakhsh:[PubMed][Scholar]
Ahmad Siadati:[PubMed][Scholar]
Mohammad Farhadi:[PubMed][Scholar]
of Medical Sciences :[PubMed][Scholar]
Shahnaz Rimaz:[PubMed][Scholar]
Azardokht Tabatabaei:[PubMed][Scholar]

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Methicillin Resistant Staphylococcus aureus in Children

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