The Effect of Exercise During Maternal Pregnancy on the Modulation of NR2B Gene Expression in the Brain of Newborn Rats

References

• 1.
  Law CK, Lam FM, Chung RC, Pang MY. Physical exercise attenuates cognitive decline and reduces behavioural problems in people with mild cognitive impairment and dementia: a systematic review. J Physiother. 2020;66(1):9-18. [PubMed ID:31843427]. https://doi.org/10.1016/j.jphys.2019.11.014.
• 2.
  Azizi-Farsani F, Shahrani-Korani M. [The Impact of Treadmill Exercise on Anxiety and Nicotine induced CPP in Mice undergoing Chronic Stress]. Koomesh J. 2023;25(5). Persian.
• 3.
  Zamani M, Radahmadi M, Reisi P. Therapeutic effects of exercise, escitalopram and exercise-accompanied escitalopram on brain functions in rats with depression. Physiol Pharmacol. 2022;26(2):188-99. https://doi.org/10.52547/phypha.26.2.7.
• 4.
  Erickson KI, Hillman C, Stillman CM, Ballard RM, Bloodgood B, Conroy DE, et al. Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines. Med Sci Sports Exerc. 2019;51(6):1242-51. [PubMed ID:31095081]. [PubMed Central ID:PMC6527141]. https://doi.org/10.1249/mss.0000000000001936.
• 5.
  Wu Y, Deng F, Wang J, Liu Y, Zhou W, Qu L, et al. Intensity-dependent effects of consecutive treadmill exercise on spatial learning and memory through the p-CREB/BDNF/NMDAR signaling in hippocampus. Behav Brain Res. 2020;386:112599. [PubMed ID:32184158]. https://doi.org/10.1016/j.bbr.2020.112599.
• 6.
  Bavi S, Navazesh A, Rasoolijazi H, Zavvari F, Soleimani M, karimzadeh F. Modulatory effect of exercise on reactive astrocytes in the somatosensory cortex of epileptic rats. Sport Sciences for Health. 2024;20(1):65-72.
• 7.
  Zavvari F, Alivan F, Abdi M, Jahanbazi Jahan-Abad A, Karimzadeh F. Maternal exercise during pregnancy increases neuregulin-1 and ErbB4 expression in the newborn offspring of Wistar rats. Sport Sciences for Health. 2022;18(3):939-45. https://doi.org/10.1007/s11332-021-00878-w.
• 8.
  Gorgij E, Fanaei H, Yaghmaei P, Shahraki MR, Mirahmadi H. Treadmill Exercise during Pregnancy Decreased Vulnerability to Neonatal Hypoxia-Ischemia through Reducing Inflammation and Increasing Antiapoptotic Gene Expressions and Antioxidant Capacity in Rats. Stroke Res Treat. 2021;2021:5512745. [PubMed ID:33936582]. [PubMed Central ID:PMC8060122]. https://doi.org/10.1155/2021/5512745.
• 9.
  Sun GC, Lee YJ, Lee YC, Yu HF, Wang DC. Exercise prevents the impairment of learning and memory in prenatally phthalate-exposed male rats by improving the expression of plasticity-related proteins. Behav Brain Res. 2021;413:113444. [PubMed ID:34245761]. https://doi.org/10.1016/j.bbr.2021.113444.
• 10.
  Yaghoobi Z, et al. [Evaluation of the effect of NMDAR agonist and antagonist on neuronal death in cerebral ischemia/reperfusion model in rats]. Koomesh J. 2023;25(5). Persian.
• 11.
  Ewald RC, Van Keuren-Jensen KR, Aizenman CD, Cline HT. Roles of NR2A and NR2B in the development of dendritic arbor morphology in vivo. J Neurosci. 2008;28(4):850-61. [PubMed ID:18216193]. [PubMed Central ID:PMC6671013]. https://doi.org/10.1523/jneurosci.5078-07.2008.
• 12.
  Sin WC, Haas K, Ruthazer ES, Cline HT. Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases. Nature. 2002;419(6906):475-80. [PubMed ID:12368855]. https://doi.org/10.1038/nature00987.
• 13.
  Zhou XM, Liu CY, Liu YY, Ma QY, Zhao X, Jiang YM, et al. Xiaoyaosan Alleviates Hippocampal Glutamate-Induced Toxicity in the CUMS Rats via NR2B and PI3K/Akt Signaling Pathway. Front Pharmacol. 2021;12:586788. [PubMed ID:33912031]. [PubMed Central ID:PMC8075411]. https://doi.org/10.3389/fphar.2021.586788.
• 14.
  Zhuang ZF, Wu HY, Song YY, Li L, Cui X, Yang J, et al. N-Methyl D-aspartate receptor subtype 2B/Ca(2+)/calmodulin-dependent protein kinase II signaling in the lateral habenula regulates orofacial allodynia and anxiety-like behaviors in a mouse model of trigeminal neuralgia. Front Cell Neurosci. 2022;16:981190. [PubMed ID:36187288]. [PubMed Central ID:PMC9521491]. https://doi.org/10.3389/fncel.2022.981190.
• 15.
  Furuie H, Yamada M. Neonatal blockade of NR2A-containing but not NR2B-containing NMDA receptor induces spatial working memory deficits in adult rats. Neurosci Res. 2022;176:57-65. [PubMed ID:34656645]. https://doi.org/10.1016/j.neures.2021.10.005.
• 16.
  Zavvari F, Modarres Mousavi SM, Ejlali M, Barfi S, Karimzadeh F. Glutamate Signaling Pathway in Absence Epilepsy: Possible Role of Ionotropic AMPA Glutamate Receptor Type 1 Subunit. Iran J Pharm Res. 2020;19(4):410-8. [PubMed ID:33841553]. [PubMed Central ID:PMC8019882]. https://doi.org/10.22037/ijpr.2020.112638.13869.
• 17.
  Martel MA, Wyllie DJ, Hardingham GE. In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience. 2009;158(1):334-43. [PubMed ID:18378405]. [PubMed Central ID:PMC2635533]. https://doi.org/10.1016/j.neuroscience.2008.01.080.
• 18.
  Zhang W, Tian F, Zheng J, Li S, Qiang M. Chronic Administration of Benzo(a)pyrene Induces Memory Impairment and Anxiety-Like Behavior and Increases of NR2B DNA Methylation. PLoS One. 2016;11(2):e0149574. [PubMed ID:26901155]. [PubMed Central ID:PMC4768874]. https://doi.org/10.1371/journal.pone.0149574.
• 19.
  Niimi K, Takahashi E, Itakura C. Improved short-term memory and increased expression of NR2B observed in senescence-accelerated mouse (SAM) P6. Exp Gerontol. 2008;43(9):847-52. [PubMed ID:18647646]. https://doi.org/10.1016/j.exger.2008.06.010.
• 20.
  Zhao D, Liu D, Chen X, Wang K, Zhang A, Kang J, et al. Prenatal stress disturbs hippocampal KIF17 and NR2B in spatial cognition in male offspring. J Neurosci Res. 2013;91(4):535-44. [PubMed ID:23239421]. https://doi.org/10.1002/jnr.23172.
• 21.
  Wang D, Li B, Wu Y, Li B. The Effects of Maternal Atrazine Exposure and Swimming Training on Spatial Learning Memory and Hippocampal Morphology in Offspring Male Rats via PSD95/NR2B Signaling Pathway. Cell Mol Neurobiol. 2019;39(7):1003-15. [PubMed ID:31187311]. [PubMed Central ID:PMC11457838]. https://doi.org/10.1007/s10571-019-00695-3.
• 22.
  Bahramian A, Mirzaei B, Karimzadeh F, Ramhmaninia F, Gaeini AA, Naderi N, et al. The Effects of Exercise Training Intensity on the Expression of C/EBPβ and CITED4 in Rats with Myocardial Infarction. Asian J Sports Med. 2018;9(4). https://doi.org/10.5812/asjsm.59300.
• 23.
  Shayan M, Mehrannia K, Rastegar T, Khanehzad M, Ghantabpour T, Hassanzadeh G. Teratogenic effect of the aqueous extract of the Foeniculum vulgare (fennel) on fetal development in mice. J Contemporary Med Sci. 2019;5(5):258-63. https://doi.org/10.22317/jcms.v5i5.657.
• 24.
  Graham AM, Rasmussen JM, Rudolph MD, Heim CM, Gilmore JH, Styner M, et al. Maternal Systemic Interleukin-6 During Pregnancy Is Associated With Newborn Amygdala Phenotypes and Subsequent Behavior at 2 Years of Age. Biol Psychiatry. 2018;83(2):109-19. [PubMed ID:28754515]. [PubMed Central ID:PMC5723539]. https://doi.org/10.1016/j.biopsych.2017.05.027.
• 25.
  Berghänel A, Heistermann M, Schülke O, Ostner J. Prenatal stress accelerates offspring growth to compensate for reduced maternal investment across mammals. Proc Natl Acad Sci USA. 2017;114(50):E10658-e66. [PubMed ID:29180423]. [PubMed Central ID:PMC5740685]. https://doi.org/10.1073/pnas.1707152114.
• 26.
  Kim CH, Lee SC, Shin JW, Chung KJ, Lee SH, Shin MS, et al. Exposure to music and noise during pregnancy influences neurogenesis and thickness in motor and somatosensory cortex of rat pups. Int Neurourol J. 2013;17(3):107-13. [PubMed ID:24143288]. [PubMed Central ID:PMC3797889]. https://doi.org/10.5213/inj.2013.17.3.107.
• 27.
  Aksu I, Baykara B, Ozbal S, Cetin F, Sisman AR, Dayi A, et al. Maternal treadmill exercise during pregnancy decreases anxiety and increases prefrontal cortex VEGF and BDNF levels of rat pups in early and late periods of life. Neurosci Lett. 2012;516(2):221-5. [PubMed ID:22503727]. https://doi.org/10.1016/j.neulet.2012.03.091.
• 28.
  Ji ES, Kim YM, Ko YJ, Baek SS. Treadmill exercise in obese maternal rats during pregnancy improves short-term memory through neurogenesis in the hippocampus of rat pups. J Exerc Rehabil. 2020;16(5):392-7. [PubMed ID:33178640]. [PubMed Central ID:PMC7609846]. https://doi.org/10.12965/jer.2040618.309.
• 29.
  Wang D, Jacobs SA, Tsien JZ. Targeting the NMDA receptor subunit NR2B for treating or preventing age-related memory decline. Expert Opin Ther Targets. 2014;18(10):1121-30. [PubMed ID:25152202]. https://doi.org/10.1517/14728222.2014.941286.
• 30.
  Ding Q, Yu Q, Tao L, Guo Y, Zhao J, Yu J. DL-3-n-butylphthalide enhances synaptic plasticity in mouse model of brain impairments. STEMedicine. 2022;3(1). https://doi.org/10.37175/stemedicine.v3i1.113.
• 31.
  Chowanadisai W, Kelleher SL, Lönnerdal B. Maternal zinc deficiency reduces NMDA receptor expression in neonatal rat brain, which persists into early adulthood. J Neurochem. 2005;94(2):510-9. [PubMed ID:15998301]. https://doi.org/10.1111/j.1471-4159.2005.03246.x.
• 32.
  Xu J, Yu L, Cai R, Zhang J, Sun X. Early auditory enrichment with music enhances auditory discrimination learning and alters NR2B protein expression in rat auditory cortex. Behav Brain Res. 2009;196(1):49-54. [PubMed ID:18706452]. https://doi.org/10.1016/j.bbr.2008.07.018.
• 33.
  Liu J, Zhao Y, Yang J, Zhang X, Zhang W, Wang P. Neonatal Repeated Exposure to Isoflurane not Sevoflurane in Mice Reversibly Impaired Spatial Cognition at Juvenile-Age. Neurochem Res. 2017;42(2):595-605. [PubMed ID:27882447]. https://doi.org/10.1007/s11064-016-2114-7.
• 34.
  Farmer J, Zhao X, van Praag H, Wodtke K, Gage FH, Christie BR. Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience. 2004;124(1):71-9. [PubMed ID:14960340]. https://doi.org/10.1016/j.neuroscience.2003.09.029.