Journal of Semnan University of Medical Sciences
Image Credit:Koomesh
Outline
Comparison of the Essential Oil and the Purified Thymoquinone in Different Varieties of Nigella sativa L. Cultivated in the Different Regions of Iran and Investigation of Their Antibacterial Activity
Authors
Abstract
Background: Pelvic floor muscle training (PFMT) is a non-pharmacological and non-invasive method for managing lower urinary tract symptoms (LUTS) in patients with multiple sclerosis (MS). This approach has attracted the attention of many studies due to its potential to improve urinary incontinence and patients' quality of life.
Objectives: This study aimed to systematically evaluate the effect of pelvic floor muscle training (PFMT) on urinary symptoms in patients with MS
Methods: The databases PubMed, Scopus, EMBASE, Web of Science, and Google Scholar were systematically searched from 2015 to April 2023. The search was conducted using related keywords, including "Multiple Sclerosis", "Pelvic Floor", and "Lower Urinary Tract Symptoms". Inclusion criteria consisted of clinical trials related to women with MS, and unrelated studies, such as letters, reviews, and case reports, were excluded. Statistical analyses were performed using STATA software (version 14.0), and to assess data heterogeneity, the random effects model and I² index were used.
Results: Out of 423 identified articles, 289 remained after removing 134 duplicates. Initial screening excluded 185 articles. The full texts of 104 articles were reviewed, and 99 were excluded because they did not meet the inclusion criteria. Finally, 5 articles involving 163 patients were included in the meta-analysis. The mean age of the patients ranged from 42 to 47 years, and the quality assessment scores ranged between 7 and 9. Study quality was evaluated using the Cochrane tool.
Conclusion: Pelvic floor muscle training significantly reduced urinary incontinence and urgency, but had no significant effect on nocturia and urinary frequency. Telerehabilitation can also be considered an effective and cost-efficient complementary method.
Highlights
References
- 1.Azadvari M, Emami Razavi SZ, Shahrooei M, Naser Moghadasi A, Azimi A, Farhadi-Shabestari HR. Bladder Dysfunction in Iranian Patients with Multiple Sclerosis. J Multidiscip Healthc. 2020;13:345-9. [PubMed ID:32308407]. [PubMed Central ID:PMC7135124]. https://doi.org/10.2147/JMDH.S244697.
- 2.Moghadasi A, Ghasemi G, Abbsi M. [Effects of total body resistance exercise on sexual function and quality of life in female with multiple sclerosis]. Koomesh J. 2021;23(5):627-35. Persian. https://doi.org/10.52547/koomesh.23.5.627.
- 3.Litwiller SE, Frohman EM, Zimmern PE. Multiple sclerosis and the urologist. J Urol. 1999;161(3):743-57. [PubMed ID:10022678].
- 4.McClurg D, Ashe RG, Marshall K, Lowe-Strong AS. Comparison of pelvic floor muscle training, electromyography biofeedback, and neuromuscular electrical stimulation for bladder dysfunction in people with multiple sclerosis: a randomized pilot study. Neurourol Urodyn. 2006;25(4):337-48. [PubMed ID:16637070]. https://doi.org/10.1002/nau.20209.
- 5.Kabay SC, Yucel M, Kabay S. Acute effect of posterior tibial nerve stimulation on neurogenic detrusor overactivity in patients with multiple sclerosis: urodynamic study. Urology. 2008;71(4):641-5. [PubMed ID:18387393]. https://doi.org/10.1016/j.urology.2007.11.135.
- 6.McClurg D, Ashe RG, Lowe-Strong AS. Neuromuscular electrical stimulation and the treatment of lower urinary tract dysfunction in multiple sclerosis--a double blind, placebo controlled, randomised clinical trial. Neurourol Urodyn. 2008;27(3):231-7. [PubMed ID:17705160]. https://doi.org/10.1002/nau.20486.
- 7.Lucio AC, Perissinoto MC, Natalin RA, Prudente A, Damasceno BP, D'Ancona C A. A comparative study of pelvic floor muscle training in women with multiple sclerosis: its impact on lower urinary tract symptoms and quality of life. Clinics (Sao Paulo). 2011;66(9):1563-8. [PubMed ID:22179160]. [PubMed Central ID:PMC3164405]. https://doi.org/10.1590/s1807-59322011000900010.
- 8.Polat Dunya C, Tulek Z, Kurtuncu M, Panicker JN, Eraksoy M. Effectiveness of the transcutaneous tibial nerve stimulation and pelvic floor muscle training with biofeedback in women with multiple sclerosis for the management of overactive bladder. Mult Scler. 2021;27(4):621-9. [PubMed ID:32513049]. https://doi.org/10.1177/1352458520926666.
- 9.Higgins JP, Altman DG, Gotzsche PC, Juni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. [PubMed ID:22008217]. [PubMed Central ID:PMC3196245]. https://doi.org/10.1136/bmj.d5928.
- 10.Ferreira AP, Pegorare AB, Salgado PR, Casafus FS, Christofoletti G. Impact of a Pelvic Floor Training Program Among Women with Multiple Sclerosis: A Controlled Clinical Trial. Am J Phys Med Rehabil. 2016;95(1):1-8. [PubMed ID:25888662]. https://doi.org/10.1097/PHM.0000000000000302.
- 11.Lucio A, D'Ancona C A, Perissinotto MC, McLean L, Damasceno BP, de Moraes Lopes MH. Pelvic Floor Muscle Training With and Without Electrical Stimulation in the Treatment of Lower Urinary Tract Symptoms in Women With Multiple Sclerosis. J Wound Ostomy Continence Nurs. 2016;43(4):414-9. [PubMed ID:27014935]. https://doi.org/10.1097/WON.0000000000000223.
- 12.Perez DC, Chao CW, Jimenez LL, Fernandez IM, de la Llave Rincon AI. Pelvic floor muscle training adapted for urinary incontinence in multiple sclerosis: a randomized clinical trial. Int Urogynecol J. 2020;31(2):267-75. [PubMed ID:31183535]. https://doi.org/10.1007/s00192-019-03993-y.
- 13.Bulbul SB, Keser I, Yucesan C, Celenay ST. Effects of pelvic floor muscle training applied with telerehabilitation in patients with multiple sclerosis having lower urinary track symptoms: A randomized controlled trial. Health Care Women Int. 2024;45(7):731-47. [PubMed ID:37010419]. https://doi.org/10.1080/07399332.2023.2190593.
- 14.Ahadi T, Raissi GR, Hosseini M, Sajadi S, Ebadi S, Mansoori K. A Randomized Clinical Trial on the Effect of Biofeedback on Pain and Quality of Life of Patients With Chronic Coccydynia. Basic Clin Neurosci. 2020;11(6):753-63. [PubMed ID:33850612]. [PubMed Central ID:PMC8019848]. https://doi.org/10.32598/bcn.11.6.1553.1.
- 15.Amarenco G, Ismael SS, Even-Schneider A, Raibaut P, Demaille-Wlodyka S, Parratte B, et al. Urodynamic effect of acute transcutaneous posterior tibial nerve stimulation in overactive bladder. J Urol. 2003;169(6):2210-5. [PubMed ID:12771752]. https://doi.org/10.1097/01.ju.0000067446.17576.bd.
- 16.Gaspard L, Tombal B, Opsomer RJ, Castille Y, Van Pesch V, Detrembleur C. [Physiotherapy and neurogenic lower urinary tract dysfunction in multiple sclerosis patients: a randomized controlled trial]. Prog Urol. 2014;24(11):697-707. French. [PubMed ID:25214451]. https://doi.org/10.1016/j.purol.2014.05.003.
- 17.Hennessey A, Robertson NP, Swingler R, Compston DA. Urinary, faecal and sexual dysfunction in patients with multiple sclerosis. J Neurol. 1999;246(11):1027-32. [PubMed ID:10631634]. https://doi.org/10.1007/s004150050508.
- 18.Giannantoni A, Scivoletto G, Di Stasi SM, Grasso MG, Agrò EF, Collura G, et al. Lower urinary tract dysfunction and disability status in patients with multiple sclerosis. Arch Physical Med Rehabili. 1999;80(4):437-41. https://doi.org/10.1016/s0003-9993(99)90282-4.
Copyright
© 2025, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
Pelvic Floor Muscle Training Instruction to Control Urinary Incontinence and its Resulting Stress, Anxiety and Depression in Patients with Multiple Sclerosis
Rafii F, Sajjadi M, Shareinia H, Sarraf P, Seyedalshohahadaee M. Pelvic Floor Muscle Training Instruction to Control Urinary Incontinence and its Resulting Stress, Anxiety and Depression in Patients with Multiple Sclerosis. Jundishapur J Chronic Dis Care. 2017;6(1):e37333. doi: https://doi.org/10.17795/jjcdc-37333
Posterior Tibial Nerve Stimulation Effect on Treatment of Overactive Bladder: A Systematic Review and Meta-analysis
Afzali M, Ghaderi F, Salehi-Pourmehr H, Soltani A. Posterior Tibial Nerve Stimulation Effect on Treatment of Overactive Bladder: A Systematic Review and Meta-analysis. Middle East J Rehabil Health Stud. 2025;12(1):e147446. doi: https://doi.org/10.5812/mejrh-147446
Prevalence of bladder and sexual dysfunctions in patients with multipl
Mazdeh M, Jafari M. Prevalence of bladder and sexual dysfunctions in patients with multipl. J Inflamm Dis. 2024;12(4):e155433. doi:
Supervised pelvic floor muscle exercise for the treatment of female urinary incontinence
Okechukwu CE. Supervised pelvic floor muscle exercise for the treatment of female urinary incontinence. J Nurs Midwifery Sci. 2021;8(1):e141439. doi: https://doi.org/10.4103/jnms.jnms_9_20
The Prevalence of Sexual Dysfunction in Iranian Women with Multiple Sclerosis: A Systematic Review and Meta-analysis
Ghasemi V, Simbar M, Ozgoli G, Nabavi SM, Alavi Majd H, et al. The Prevalence of Sexual Dysfunction in Iranian Women with Multiple Sclerosis: A Systematic Review and Meta-analysis. Shiraz E-Med J. 2019;20(6):e83490. doi: https://doi.org/10.5812/semj.83490
More by these authors
- Scopus by DOI: 0
Last Update: 3 weeks ago
- Scopus by Title: 0
Last Update: 3 weeks ago
- Scopus by Title (Ref): 0
Last Update: 3 weeks ago
- CrossRef: 0
Last Update: 6 days ago
- OpenAlex: 0
Last Update: 1 day ago
- OpenCitations: 0
Last Update: 4 days ago
