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Journal of Semnan University of Medical Sciences

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koomesh

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https://doi.org/10.69107/koomesh-157745

The Anti-cancer Effect of the Methanolic Extract of Rhamnus cathartica on AGS and MNK45 Cell Lines In Vitro

Author(s):
Ehsan LotfabadiEhsan Lotfabadi1, Aroona ChabraAroona Chabra2, Bahman Rahimi EsboeiBahman Rahimi EsboeiBahman Rahimi Esboei ORCID2, 3,*, Maryam HataminejadMaryam HataminejadMaryam Hataminejad ORCID2
1Department of Phamacognosy, School of Pharmacology, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.
2Department of Parasitology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
3Toxoplasmosis Research Center, Communicable Diseases Institute, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Koomesh:Vol. 27, issue 3; e157745
Published online:Jul 01, 2025
Article type:Research Article
How to Cite:Lotfabadi E, Chabra A, Rahimi Esboei B, Hataminejad M. The Anti-cancer Effect of the Methanolic Extract of Rhamnus cathartica on AGS and MNK45 Cell Lines In Vitro.koomesh.2025;27(3):e157745.https://doi.org/10.69107/koomesh-157745.

Abstract

Keywords
Gastrointestinal Neoplasms
Cell line
Rhamnus

References

  • 1.
    Hanahan D. Hallmarks of Cancer: New Dimensions. Cancer Discov. 2022;12(1):31-46. [PubMed ID:35022204]. https://doi.org/10.1158/2159-8290.CD-21-1059.
  • 2.
    Wan ML, Wang Y, Zeng Z, Deng B, Zhu BS, Cao T, et al. Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways. Biosci Rep. 2020;40(3). [PubMed ID:32149326]. [PubMed Central ID:PMC7087324]. https://doi.org/10.1042/BSR20200265.
  • 3.
    Oppegaard KR, Mayo SJ, Armstrong TS, Kober KM, Anguera JA, Wright F, et al. An Evaluation of the Multifactorial Model of Cancer-Related Cognitive Impairment. Nurs Res. 2023;72(4):272-80. [PubMed ID:37104681]. [PubMed Central ID:PMC10330009]. https://doi.org/10.1097/NNR.0000000000000660.
  • 4.
    Dragojlovic N, Borle K, Kopac N, Ellis U, Birch P, Adam S, et al. The composition and capacity of the clinical genetics workforce in high-income countries: a scoping review. Genet Med. 2020;22(9):1437-49. [PubMed ID:32576987]. https://doi.org/10.1038/s41436-020-0825-2.
  • 5.
    Elrebehy MA, Al-Saeed S, Gamal S, El-Sayed A, Ahmed AA, Waheed O, et al. miRNAs as cornerstones in colorectal cancer pathogenesis and resistance to therapy: A spotlight on signaling pathways interplay - A review. Int J Biol Macromol. 2022;214:583-600. [PubMed ID:35768045]. https://doi.org/10.1016/j.ijbiomac.2022.06.134.
  • 6.
    Shishesaz P, Mahdavi M, Ghodratpour F. [Evaluation of Cytotoxic and Apoptotic Effects of Green Synthesized Zn Oxide Nanoparticles on the MCF-7 breast cancer Cell Line]. Koomesh. 2023;25(2):270-8. Persian.
  • 7.
    Murphy CC, Zaki TA. Changing epidemiology of colorectal cancer - birth cohort effects and emerging risk factors. Nat Rev Gastroenterol Hepatol. 2024;21(1):25-34. [PubMed ID:37723270]. https://doi.org/10.1038/s41575-023-00841-9.
  • 8.
    Rodger EJ, Gimenez G, Ajithkumar P, Stockwell PA, Almomani S, Bowden SA, et al. An epigenetic signature of advanced colorectal cancer metastasis. iScience. 2023;26(6):106986. [PubMed ID:37378317]. [PubMed Central ID:PMC10291510]. https://doi.org/10.1016/j.isci.2023.106986.
  • 9.
    Sadrifar S, Erfanian S, Baharlou R. [The effect of fresh frozen plasma (FFP) and human platelet lysate (HPL) on the proliferation rate of human mesenchymal stem cells (MSCs) derived from adipose tissue and umbilical cord blood]. Koomesh. 2023;25(3):385-93. Persian.
  • 10.
    Chen JF, Wu SW, Shi ZM, Hu B. Traditional Chinese medicine for colorectal cancer treatment: potential targets and mechanisms of action. Chin Med. 2023;18(1):14. [PubMed ID:36782251]. [PubMed Central ID:PMC9923939]. https://doi.org/10.1186/s13020-023-00719-7.
  • 11.
    Hernandez Dominguez O, Yilmaz S, Steele SR. Stage IV Colorectal Cancer Management and Treatment. J Clin Med. 2023;12(5). [PubMed ID:36902858]. [PubMed Central ID:PMC10004676]. https://doi.org/10.3390/jcm12052072.
  • 12.
    Jiang H, Zuo J, Li B, Chen R, Luo K, Xiang X, et al. Drug-induced oxidative stress in cancer treatments: Angel or devil? Redox Biol. 2023;63:102754. [PubMed ID:37224697]. [PubMed Central ID:PMC10220276]. https://doi.org/10.1016/j.redox.2023.102754.
  • 13.
    Motyka S, Jafernik K, Ekiert H, Sharifi-Rad J, Calina D, Al-Omari B, et al. Podophyllotoxin and its derivatives: Potential anticancer agents of natural origin in cancer chemotherapy. Biomed Pharmacother. 2023;158:114145. [PubMed ID:36586242]. https://doi.org/10.1016/j.biopha.2022.114145.
  • 14.
    Su Y, Zhao B, Zhou L, Zhang Z, Shen Y, Lv H, et al. Ferroptosis, a novel pharmacological mechanism of anti-cancer drugs. Cancer Lett. 2020;483:127-36. [PubMed ID:32067993]. https://doi.org/10.1016/j.canlet.2020.02.015.
  • 15.
    Rushdi M, Fouda WM, Mohamed AD. Natural product diversity of Buckthorns (Rhamnus cathartica and Rhamnus disperma). Octahedron Drug Res. 2024;5(1):51-63.
  • 16.
    Rahimi Esboei B, Chabra A, Hedayati P, Parandin F. Anti-leishmaniasis activity of Rhamnus cathatica on amastigote stages of Leishmania major. Int J Mol Clin Microbiol. 2023;13(1):1802-9.
  • 17.
    Khuda F, Alam N, Khalil AAK, Jan A, Naureen F, Ullah Z, et al. Screening of Rhamnus Purpurea (Edgew.) Leaves for Antimicrobial, Antioxidant, and Cytotoxic Potential. ACS Omega. 2022;7(26):22977-85. [PubMed ID:35811929]. [PubMed Central ID:PMC9260770]. https://doi.org/10.1021/acsomega.2c03094.
  • 18.
    Lamari FN, Cordopatis P. Exploring the potential of natural products in cancer treatment. In: Missailidis S, editor. Anticancer Therapeutics. Hoboken, New Jersey: Wiley; 2008. p. 1-16.
  • 19.
    Chabra A, Rahimi-Esboei B, Habibi E, Monadi T, Azadbakht M, Elmi T, et al. Effects of some natural products from fungal and herbal sources on Giardia lamblia in vivo. Parasitology. 2019;146(9):188-98. [PubMed ID:31006397]. https://doi.org/10.1017/S0031182019000325.
  • 20.
    Zafari F, Sadeghi M, Moghanloo E, Bakhtiyari M. [Assessment of CD93 Stem Cell Growth and Survival on Three-Dimensional Biodegradable PCL-Gelatin Scaffold]. J Mazandaran Univ Med Sci. 2017;26(144):211-8. Persian.
  • 21.
    Rahimi MT, Ahmadpour E, Rahimi Esboei B, Spotin A, Kohansal Koshki MH, Alizadeh A, et al. Scolicidal activity of biosynthesized silver nanoparticles against Echinococcus granulosus protoscolices. Int J Surg. 2015;19. [PubMed ID:26028438]. https://doi.org/10.1016/j.ijsu.2015.05.043.
  • 22.
    Jakubczyk K, Druzga A, Katarzyna J, Skonieczna-Zydecka K. Antioxidant Potential of Curcumin-A Meta-Analysis of Randomized Clinical Trials. Antioxidants (Basel). 2020;9(11). [PubMed ID:33172016]. [PubMed Central ID:PMC7694612]. https://doi.org/10.3390/antiox9111092.
  • 23.
    Lin D, Xiao L, Qin W, Loy DA, Wu Z, Chen H, et al. Preparation, characterization and antioxidant properties of curcumin encapsulated chitosan/lignosulfonate micelles. Carbohydr Polym. 2022;281:119080. [PubMed ID:35074131]. https://doi.org/10.1016/j.carbpol.2021.119080.
  • 24.
    Pricci M, Girardi B, Giorgio F, Losurdo G, Ierardi E, Di Leo A. Curcumin and Colorectal Cancer: From Basic to Clinical Evidences. Int J Mol Sci. 200;7)). [PubMed ID:32235371]. [PubMed Central ID:PMC7178200]. https://doi.org/10.3390/ijms21072364.
  • 25.
    Mansouri K, Rasoulpoor S, Daneshkhah A, Abolfathi S, Salari N, Mohammadi M, et al. Clinical effects of curcumin in enhancing cancer therapy: A systematic review. BMC Cancer. 2020;20(1):791. [PubMed ID:32838749]. [PubMed Central ID:PMC7446227]. https://doi.org/10.1186/s12885-020-07256-8.
  • 26.
    Mohankumar K, Francis AP, Pajaniradje S, Rajagopalan R. Synthetic curcumin analog: inhibiting the invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells via NF-kB pathway. Mol Biol Rep. 2021;48(8):6065-74. [PubMed ID:34355287]. https://doi.org/10.1007/s11033-021-06610-8.
  • 27.
    Wang T, Wu X, Al Rudaisat M, Song Y, Cheng H. Curcumin induces G2/M arrest and triggers autophagy, ROS generation and cell senescence in cervical cancer cells. J Cancer. 2020;11(22):6704-15. [PubMed ID:33046993]. [PubMed Central ID:PMC7545669]. https://doi.org/10.7150/jca.45176.
  • 28.
    Rainey NE, Moustapha A, Petit PX. Curcumin, a Multifaceted Hormetic Agent, Mediates an Intricate Crosstalk between Mitochondrial Turnover, Autophagy, and Apoptosis. Oxid Med Cell Longev. 2020;2020. [PubMed ID:32765806]. [PubMed Central ID:PMC7387956]. https://doi.org/10.1155/2020/3656419.
  • 29.
    Ghaffari M, Dehghan G, Baradaran B, Zarebkohan A, Mansoori B, Soleymani J, et al. Co-delivery of curcumin and Bcl-2 siRNA by PAMAM dendrimers for enhancement of the therapeutic efficacy in HeLa cancer cells. Colloids Surf B Biointerfaces. 2020;188:110762. [PubMed ID:31911391]. [PubMed Central ID:PMC7071519]. https://doi.org/10.1016/j.colsurfb.2019.110762.
  • 30.
    Sanders B, Ray AM, Goldberg S, Clark T, McDaniel HR, Atlas SE, et al. Anti-cancer effects of aloe-emodin: a systematic review. J Clin Transl Res. 2018;3(3):283-96. [PubMed ID:30895270]. [PubMed Central ID:PMC6426255].
  • 31.
    Park MY, Kwon HJ, Sung MK. Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Biosci Biotechnol Biochem. 2009;73(4):828-32. [PubMed ID: https://doi.org/10.1271/bbb.80714.
  • 32.
    Chun-Guang W, Jun-Qing Y, Bei-Zhong L, Dan-Ting J, Chong W, Liang Z, et al. Anti-tumor activity of emodin against human chronic myelocytic leukemia K562 cell lines in vitro and in vivo. Eur J Pharmacol. 2010;627(1-3):33-41. [PubMed ID:19857484]. https://doi.org/10.1016/j.ejphar.2009.10.035.
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