The effect of selenase on the disease process of patients with septic shock admitted to the intensive care unit: A clinical trial in Tehran

authors:

avatar Ebrahim Hazrati 1 , avatar Mohammad Reza Rafii Rafii 1 , avatar behzad kazemi haki 2 , * , avatar Babak Shekarchi 3 , avatar Seyed Javad Hosseini-Shokouh 4

Department of Anesthesiology, AJA University of Medical Sciences, Tehran, Iran, Andorra
Bachelor of Anesthesiology, Tabriz University of Medical Sciences, Tabriz, Iran, Andorra
Department of radiology, AJA University of Medical Sciences, Tehran, Iran, Andorra
Department of Infectious Diseases and Tropical Medicine, AJA University of Medical Sciences, Tehran, Iran., Andorra
Annals of Military and Health Sciences Research: Vol.13, issue 1; e62678
published online: April 24, 2015
article type: Original Article
received: January 21, 2015
accepted: March 24, 2015

how to cite: Hazrati E , Rafii M R R, kazemi haki B, Shekarchi B , Hosseini-Shokouh S J. The effect of selenase on the disease process of patients with septic shock admitted to the intensive care unit: A clinical trial in Tehran. Ann Mil Health Sci Res. 2015;13(1):e62678. 

Abstract

Materials and Methods: This double-blind clinical trial was done on 80 participants (40 case and 40 control) who were admitted to the ICU with septic shock. Every participant in the case group was administered 500 μg selenase twice daily for 10 days. In contrast, each participant of the control group was treated with placebo (normal saline). Data were collected by observation and recorded in a questionnaire. Chi-square and Student’s t-test were used for data analysis. Results: In this study 34 participants (42.5%) were men and 46 (57.5%) were women. The duration stay in the ICU in treatment group was less than in the observation group which was statistically significant (P = .01). There was also a significant difference regarding the frequency of morbidity and mortality rates between the two groups (P = .03 and P = .02, respectively). Conclusion: Selenium at a dosage of 500 μg (twice daily) is effective in those who have suffered from septic shock. Still, more studies are needed to determine the best dosage and administration method of this   drug.

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