The effect of bromocriptine-rebound method on ongoing pregnancy and live birth after intracytoplasmic sperm injection cycles: a randomized clinical trial

authors:

avatar Ashraf Alleyassin 1 , avatar Ramak Esmailizad 2 , avatar Marzieh Agha-Hosseini 1 , avatar Leila Safdarian 1 , avatar Fatemeh Sarvi 1 , * , avatar Abas Kokab 2

Department of Infertility, Tehran University of Medical Sciences, Tehran, Iran, Andorra
Department of Infertility, Tehran University of Medical Sciences, Tehran, Iran., Andorra
Annals of Military and Health Sciences Research: Vol.12, issue 3; e63508
published online: October 29, 2014
article type: Original Article
received: June 17, 2014
accepted: August 28, 2014

how to cite: Alleyassin A , Esmailizad R, Agha-Hosseini M , Safdarian L , Sarvi F , et al. The effect of bromocriptine-rebound method on ongoing pregnancy and live birth after intracytoplasmic sperm injection cycles: a randomized clinical trial. Ann Mil Health Sci Res. 2014;12(3):e63508. 

Abstract

Materials and Methods: A total of 114 women underwent ICSI. Pregnancy outcomes and hormonal data were compared between two groups, i.e. long protocol and BRM. Ovulatory women with normal serum prolactin levels were assigned to either BRM (n = 57 cycles) or  long protocol (n = 57 cycles). Both procedures were carried out in a similar way. However, a group of patients were given bromocriptine daily from the 4th day of the preceding cycle until      7 days before gonadotropin   stimulation.

Results: There were no significant differences in the numbers of developed follicles,total retrieval oocytes, transferredembryo and embryos with superior morphology between the two groups. Also, the values of chemical, clinical and ongoing pregnancies and live births were not significantly different (36.8%, 35.1%, 28.1%, 28.1% in BRM group and 43.9%, 38.6%, 21.1% and 19.3%      in long protocol, respectively). Ongoing pregnancy and live birth were significantly higher in chemical pregnancy in the BRM group (P = .04 and P = .035, respectively).

Conclusion: This prospective study demonstrated that BRM might lead to higher ongoing pregnancy and live birth rates compared to the long protocol in women undergoing intracytoplasmic sperm  injection cycles.

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