Brain-derived neurotrophic factor, insulin-like growth factor 1 and its binding protein responses to  a session of endurance exercises in healthy elderly men

Fariborz  Hovanloo; mohsen shabani; Khosro  Ebrahim; Mehdi  Hedayati

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Brain-derived neurotrophic factor, insulin-like growth factor 1 and its binding protein responses to a session of endurance exercises in healthy elderly men

Author(s):

Fariborz Hovanloo¹,

mohsen shabani^2,*,

Khosro Ebrahim³,

Mehdi Hedayati⁴

1Department of Physical Education and Sports Science, Shahid Beheshti University, Tehran, Iran., Andorra

2Department of Physical Education and Sports Science, Shahid Beheshti University, Tehran, Iran, Andorra

3Department of Physical Education and Sports Science, Shahid Beheshti University, Tehran, Iran., Andorra

4Department of Clinical Biochemistry, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Andorra

Annals of Military and Health Sciences Research:Vol. 12, issue 1; e63523

Published online:Feb 18, 2014

Article type:Research Article

Received:Oct 16, 2013

Accepted:Dec 19, 2013

How to Cite:Fariborz Hovanloomohsen shabaniKhosro EbrahimMehdi HedayatiBrain-derived neurotrophic factor, insulin-like growth factor 1 and its binding protein responses to a session of endurance exercises in healthy elderly men.Ann Mil Health Sci Res.12(1):e63523.

Abstract

Materials and Methods: Eleven healthy old males (mean age of 68 ± 2.31 years old, height of 177 ± 3.1 cm and weight of 79 ± 1.5 kg) were studied. Seventy two hours after maximal oxygen consumption (VO2 max) evaluation, the participants performed an endurance activity at the intensity of 70% of their VO2 max. Three blood samples were collected from the antecubital vein before, immediately and 30 minutes after the activity. The data were analyzed by repeated measures (P ≤ .05).

Results: There was a significant increase in serum BDNF and IGF-1 immediately after the endurance activity (P = .040 and P = .047, respectively). However, 30 minutes after the activity, there were no significant changes in serum BDNF and IGF-1 compared to the serums before the activity. There was also no significant change in IGFBP-3 immediately and 30 minutes after the research protocol relative to serums before activity (P = .067 and P = .154, respectively).

Conclusion: The findings showed that BDNF and IGF-1 increase significantly in response to endurance activity, but no significant change was observed in IGFBP-3. Endurance activities might contribute to an increase in neurotrophical factors involved in memory and cognitive function which in turn decrease the incidence of neurological diseases such as Alzheimer, depression and many other related neurophysiological ones in elderly adults

Keywords

brain-derived neurotrophic factor (BDNF

insulin-like growth factor 1 (IGF-1

insulin-like growth factor binding protein 3 (IGFBP-3)

endurance exercise

elderly men

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