The most sensitive double-marker method of cardiac isoenzymes of creatinine kinase, troponin I, and myoglobin in different time periods for diagnosing acute myocardial infarction

Kiumars  Ahmadi; Fahimeh  Dadgari; Mohammad Reza Safarinejadi Aghdam

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The most sensitive double-marker method of cardiac isoenzymes of creatinine kinase, troponin I, and myoglobin in different time periods for diagnosing acute myocardial infarction

Author(s):

Kiumars Ahmadi¹,

Fahimeh Dadgari ¹,

Mohammad Reza Safarinejadi Aghdam^2,*

1Department of Biochemistry, Bessat General Hospital, Aja University of Medical Sciences, Tehran, Iran, Andorra

2Private Practice of Urology and Andrology, Tehran, Iran, Andorra

Annals of Military and Health Sciences Research:Vol. 12, issue 1; e63561

Published online:Jan 22, 2014

Article type:Research Article

Received:Jun 12, 2013

Accepted:Dec 10, 2013

How to Cite:Kiumars AhmadiFahimeh Dadgari Mohammad Reza Safarinejadi AghdamThe most sensitive double-marker method of cardiac isoenzymes of creatinine kinase, troponin I, and myoglobin in different time periods for diagnosing acute myocardial infarction.Ann Mil Health Sci Res.12(1):e63561.

Abstract

Materials and Methods: This was an observational-analytic research on a diagnostic test conducted on 256 patients who had referred to the emergency department with chest pain from 4 to 24 hours before their referral. They were sorted equally into two groups of 4-14 hours and 15-24 hours from onset of pain, each group including 128 patients.

Results: In the first time period, the combination of troponin and myoglobin had the highest sensitivity (sensitivity = 97.3%, specificity = 98.1%), whereas the combination of double-marker and troponin proved the most sensitive (sensitivity = 100%, specificity = 96.3%).

Conclusion: The double-marker combination of troponin and myoglobin is more appropriate for the first time period (i.e. during the first 24 hours from the onset of chest pain),while it would be more helpful to use the combination of troponin during the second period of time.

Keywords

myocardial infarction

isoenzyme of creatinine kinase

troponin

myoglobin

diagnosis

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