Effect of surgery stress and immobilization stress on ghrelin hormone level, body weight and food intake in female rats

Zohre Genabzadeh Jahromy; Parvin Zareian; Habiboalah Johary; Hosein Kargar Jahromy

Annals of Military and Health Sciences Research

Current Issue All Issues In Press Accepted Manuscripts Search

Journal Information Editors and Boards Indexing and Listing Sources Reviewer and AE Registration Form Journal Metrics Open Peer Review (OPR)Publication Ethics and Malpractice Statement Contact Us Support

Authors Guide Submit Manuscript

Effect of surgery stress and immobilization stress on ghrelin hormone level, body weight and food intake in female rats

Author(s):

Zohre Genabzadeh Jahromy¹,

Parvin Zareian^2,*,

Habiboalah Johary³,

Hosein Kargar Jahromy⁴

1Researcher, Biology Department, Jahrom Azad University, Jahrom, Iran, Andorra

2Associate Professor, Physiology Department, AJA University of Medical Sciences, Tehran, Iran, Iran

3Assistant Professor, Biology Department, Darab Azad University, Darab, Iran, Andorra

4Instructor, Biology Department, Jahrom Azad University, Jahrom, Iran, Andorra

Annals of Military and Health Sciences Research:Vol. 11, issue 1; e66742

Published online:Mar 14, 2013

Article type:Research Article

Received:Nov 28, 2012

Accepted:Feb 14, 2013

How to Cite: Zohre Genabzadeh JahromyParvin Zareian Habiboalah Johary Hosein Kargar JahromyEffect of surgery stress and immobilization stress on ghrelin hormone level, body weight and food intake in female rats.Ann Mil Health Sci Res.11(1):e66742.

Abstract

Background: Animal models of stress are a good for studying the stress induced disorders. The present study investigated the effect of immobilization and surgery stress on plasma ghrelin concentration, food intake and body weight.

Materials and Methods: This was an experimental study. 40 adult female rats were divided into 4 groups. Control group: no stress. In sham Group anesthetic and antibiotic drugs were administered. Surgery group rats were subjected surgery stress. Immobilization group rats were subjected to immobilization stress for 7 days. On the seventh day, blood samples were obtained directly from the animal’s heart. Serum Ghrelin concentrations were measured by ELISA. The changes in body weight during 7 days were recorded. Food intake was measured daily.

Results: Surgical stress had no significant effect on serum ghrelin concentrations but immobilization stress caused a significant increase in blood levels of ghrelin. Surgery and immobilization stress had no significant effect on body weight. Immobilization stress caused a significant increase in food intake.

Conclusion: The effect of Stress on serum ghrelin level and food intake depends on the kind of stress.

Keywords

Fulltext

full text is available in pdf

References

1.
References are available in pdf.

comments