Modern Methods to Repair Orthopedic Injuries through Stem Cells Approach in Bone Tissue Engineering

Masoud  Hafezi; Mostafa  Shahrezaie; Mohammad Hossein  Lashgari; Banafshe  Dormanesh; Mohammadali sahebalzamani

Annals of Military and Health Sciences Research

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Modern Methods to Repair Orthopedic Injuries through Stem Cells Approach in Bone Tissue Engineering

Author(s):

Masoud Hafezi¹,

Mostafa Shahrezaie²,

Mohammad Hossein Lashgari³,

Banafshe Dormanesh⁴,

Mohammadali sahebalzamani^5,*

1Assistant Professor, Department of Biomaterials of Nanotechnology and Advanced Materials, Materials and Energy Research center, Alborz, Iran, Andorra

2Assistant Professor, Department of Orthopedic, AJA University of Medical Sciences, Tehran, Iran, Andorra

3Assistant Professor, Department of Surgery, AJA University of Medical Sciences, Tehran, Iran, Andorra

4Assistant Professor, Department of Pediatrics, AJA University of Medical Sciences, Tehran, Iran, Andorra

5Researcher, Department of Biomedical Engineering, Islamic Azad University, Sciences and Research Branch, Tehran, Iran., Andorra

Annals of Military and Health Sciences Research:Vol. 11, issue 1; e67411

Published online:Mar 13, 2013

Article type:Review Article

Received:Oct 30, 2012

Accepted:Feb 13, 2013

How to Cite:Masoud HafeziMostafa ShahrezaieMohammad Hossein LashgariBanafshe DormaneshMohammadali sahebalzamaniModern Methods to Repair Orthopedic Injuries through Stem Cells Approach in Bone Tissue Engineering.Ann Mil Health Sci Res.11(1):e67411.

Abstract

Background: In today’s modern and mechanical world, humans are exposed to a wide range of bone tissue diseases and injuries. Most of these injuries can be treated using conventional medical methods, but some are considered incurable or refractory. These injuries are often those in which large parts of bone tissue have been destroyed and natural body mechanisms are not able to rebuild the damaged tissue. A branch of medical sciences called the regenerative medicine is responsible for treating such injuries. One of the tools of regenerative medicine is the transplantation of bone-like structures made by tissue engineering method.

Results: Bone tissue engineering is benefitted from three main parts including the cell, the scaffold and the growth factor. The use of mesenchymal stem cells as the cell factor in the design of engineering scaffold, has been greatly facilitated the construction process of bone structures and revolutionized the field of bone tissue engineering. Such effects of mesenchymal stem cells are due to their self-renewal ability and high potential to differentiate into bones while not stimulating the immune system. The culture of osteoblasts on porous scaffolds can be a new solution for bone transplantation using the person’s own mesenchymal cells.

Conclusions: In-vivo studies and the obtained clinical results also showed that treating injuries using this strategy is completely reliable. Scientists try to attain modern treatment methods to treat different kinds of skeletal tissue injuries of the body in the near future through developing this strategy and employing new innovations such as the use of nanoparticles or nanostructured scaffolds.

Keywords

Tissue Engineering

Bone and Bones Stem Cells

Tissue Scaffold

Orthopedics

Wounds and Injuries

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