Immunomodulatory effects of Aloe Vera on of the fungus Candida Albicans in animal model

Zohre Farahnejad; Tooba  Ghazanfari; Mahtab  Noorifard

Annals of Military and Health Sciences Research

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Immunomodulatory effects of Aloe Vera on of the fungus Candida Albicans in animal model

Author(s):

Zohre Farahnejad^1,*,

Tooba Ghazanfari²,

Mahtab Noorifard³

1Assistant Professor, Aja University of Medical Sciences, Dept. of Parasitology, Tehran, Iran, Iran

2Professor, Shahed University of Medical Sciences, Dept. of Immunology, Tehran, Iran, Andorra

3Assistant Professor, Aja University of Medical Sciences, Dept. of Infectious Disease, Tehran, Iran, Andorra

Annals of Military and Health Sciences Research:Vol. 10, issue 4; e67526

Published online:Jan 03, 2013

Article type:Research Article

Received:Oct 18, 2012

Accepted:Dec 03, 2012

How to Cite:Zohre FarahnejadTooba GhazanfariMahtab NoorifardImmunomodulatory effects of Aloe Vera on of the fungus Candida Albicans in animal model.Ann Mil Health Sci Res.10(4):e67526.

Abstract

Background: Natural products are important resources in herbal medicines and have been long used for prevention and treatment of many diseases. Aloe vera has been shown to modulate the immune response. Candidiasis is one of the most common fungal infections and Candida albicans has become the fourth most common cause of hospital infections. so in this article the effects of Aloe vera plant extracts on macrophage activation has evaluated.

Materials and Methods: First of all we infected the 5 groups of the mice with Candida Albicans and then allowed the Candida to activate in one week. Then the Aloe Vera extract (has) injected to mice. Then intraperitoneal macrophages of mice has got and in the end MTT test (has been) performed in order to evaluate the viability of intraperitoneal macrophages.

Results: In vivo results show that all of doses of the Aloe Vera extract 100mg/kg، 50، 20،10 significantly increased cell viability in presence of mitogen.

Conclusion: This study showed Aloe Vera extracts in the In vivo in presence of immune stimulator has an effective role in stimulating the immune system (in). In Further studies, processing such as isolation and purification of aloe vera components, are necessary to clarify the modulatory effects of aloe vera on macrophage function.

Keywords

aloe vera

Immunomodulator

Candida Albicans

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