The Cerebrolysin efficacy in acute ischemic stroke

Mohammad Aminianfar; Hossein ali  Salehi; Ali Asghar Saidi; Alireza Ranjbar naeeni; Negar Kaveh

Annals of Military and Health Sciences Research

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The Cerebrolysin efficacy in acute ischemic stroke

Author(s):

Mohammad Aminianfar¹,

Hossein ali Salehi^2,*,

Ali Asghar Saidi³,

Alireza Ranjbar naeeni³,

Negar Kaveh⁴

1Assistant Professor, Department of Infectious and Tropical Disease, Be'sat Hospital, Medical Faculty, AJA University of Medical Sciences, Tehran, Iran, Andorra

2Assistant Professor, Department of Neurology, AJA University of Medical Sciences, Tehran, Iran, Andorra

3Assistant Professor, Department of Neurology, Be'sat Hospital, AJA University of Medical Sciences, Tehran, Iran, Andorra

4Medical Researcher, General Physician, Tehran, Iran, Andorra

Annals of Military and Health Sciences Research:Vol. 10, issue 4; e67809

Published online:Dec 05, 2012

Article type:Research Article

Received:Jul 18, 2012

Accepted:Nov 17, 2012

How to Cite:Mohammad AminianfarHossein ali SalehiAli Asghar SaidiAlireza Ranjbar naeeniNegar KavehThe Cerebrolysin efficacy in acute ischemic stroke.Ann Mil Health Sci Res.10(4):e67809.

Abstract

Background: Cerebrolysin, a preparation of low molecular weight neuropeptide and free amino acids, has been shown to have a great affect against excitotoxicity, inhibiting free radical formation, microglia activation and additionally neurotrophic action, promoting neuronal sprouting, and improving cellular survival and stimulating neurogenesis following stroke. The aim of this study was to determine the efficacy of Cerebrolysinon acute ischemic stroke.

Materials and Methods: The present study was a randomised double blind clinical trial. The sample was 89 patients with confirmed the diagnosis of acute ischemic stroke. The patients divided in the intervention or control group with simple randomization. Patients in intervention group received 50ml cerebrolysin diluted in 100ml normal saline solution (totally 150 ml) infused over a time period of 30 minutes for 7 days and for control group patients, administered just 150ml normal saline infusion. Patients were assessed on days 1, 30 and 90 by Orgogozo, barthel index, MRS and NIHSS score.

Results: The findings indicated that the mean of scores at the end of the first month was increased in comparision with the first day, 1.68 in intervention and -10.95 in intervention and case groups respectively and these differences were meaningful statistically (p<0.05). The comparison of scores at the end of three month treatment to the first day reported meaningful too (p<0.05). The findings demonstrated that at the end of the third month as compared with the first day, added 1.68 to case group score and reduced -13.21 from the control group score.

Conclusion: Cerebrolysin is efficient in acute ischemic stroke patients and decreases the tissue damage severity in these patients. On the other hand, presumably it can reduces disabillity of the disease.

Keywords

Acute Ischemic Stroke

Cerebrolysin

Thrombolytic

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