The synthesis of chitosan / polyethylene nanofibersoxide on chitosan membrane: an applicable model in tissue engineering

authors:

avatar Asgar Emamgholi 1 , avatar gholamreza Kaka 2 , * , avatar Mino Sadri 3 , avatar Seyyed Homayoon Sadraee 4 , avatar Seyyed Hasan Hosseini 5

Researcher, MSc in Nano-biotechnology, Neuroscience Research Center and Nano-biotechnology research center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Andorra
Assistant Professor, Neuroscience Research Center and Anatomy Department, Baqiyatallah University of Medical Sciences, Tehran, Iran, Andorra
Assistant Professor, Biological Technology Research Institue, Malek Ashtar University of Technology, Tehran, Iran, Andorra
Associated Professor, Neuroscience Research Center and Anatomy Department, Baqiyatallah University of Medical Sciences, Tehran, Iran, Andorra
Researcher, MSc in Nano-biotechnology, Industrial research center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Andorra
Annals of Military and Health Sciences Research: Vol.10, issue 4; e67930
published online: December 04, 2012
article type: Original Article
received: July 11, 2012
accepted: November 11, 2012

how to cite: Emamgholi A , Kaka G, Sadri M , Sadraee S H , Hosseini S H . The synthesis of chitosan / polyethylene nanofibersoxide on chitosan membrane: an applicable model in tissue engineering. Ann Mil Health Sci Res. 2012;10(4):e67930. 

Abstract

Background: Nanofibers as nano-scaffolds are widely used in tissue engineering. . Electrospun is a way to produce these fiberes. In this study, the synthesis of chitosan nanofibers / polyethylene oxide (CS / PEO) on a very thin membrane of CS as a basement membrane has been investigated.
Materials and Methods: For this purpose, composite solutions with volume fractions - density of CS and PEO, respectively, with ratios of 100 to zero (pure chitosan), 90 to 10 and 80 to 20 in Acetic Acid 5/0 M were prepared. Interactions of two polymers on each other were studied by Fourier transform infra-red spectroscopy (FTIR). Nanofiber diameter and size were studied with Scanning Electron Microscope (SEM). CS membrane polymer solution on the interval the electric field kv 20-18 cm 15-10 and feed rate ml / h 5/0 was electrospun. Nanofiber diameter and size were studied by Scanning Electron Microscope (SEM).
Results: FTIR study of the composite CS / PEO ratio of 20/80 and 10/90 peak tensile bond hydroxyl (OH) and (C = O) chitosan showed in certain areas. Scanning Electron Microscopic images showed that pure CS could not produce nanofibers on any ratios, and they appeared as a droplet. Whereas, nanofibers were created with ratios 80 to 20 and 90 to 10 of CS / PEO composite both on the aluminum foils and thin membrane of CS.
Conclusion: It seems that high viscosity of pure CS prevents nanofibers formation. Whereas, homogeneous nanofibers obtained from the composite of CS / PEO with the ratios 80 to 20, 90 to 10 and pure CS on thin membrane of CS.

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