Molecular Aspects of Hepatocellular Carcinoma Caused by Hepatitis C Virus

Ali Karami; Seyed Alavian; Ali Najafi; Mohammad Hosseini

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Molecular Aspects of Hepatocellular Carcinoma Caused by Hepatitis C Virus

Author(s):

Ali Karami^1,*,

Seyed Moayed Alavian²,

Ali Najafi²,

Mohammad Javad Hosseini²

1Research Center of Molecular biology, Baqiyatallah University of Medical Sciences, Karami@bmsu.ac.ir, Tehran, IR.Iran

2Liver and Gastroentestinal Research Center, Baqiyatallah University of Medical Sciences and Tehran Hepatitis Center, Tehran, IR.Iran

Hepatitis Monthly:Vol. 6, issue 2; 75-82

Article type:Review Article

Received:May 12, 2006

Accepted:May 25, 2006

How to Cite:Ali KaramiSeyed Moayed AlavianAli NajafiMohammad Javad HosseiniMolecular Aspects of Hepatocellular Carcinoma Caused by Hepatitis C Virus.Hepat Mon.6(2):75-82.

Abstract

The hepatitis C virus (HCV) is a small, enveloped, single-stranded positive sense RNA virus with a diameter of about 50 nm belonging to the Hepacivirus genus of the family Flaviviridae. The HCV genome is translated to produce a single protein of around 3011 amino acids. This "polyprotein" is then proteolytically processed by viral and cellular proteases to produce structural (core protein, envelope glycoproteins E1 and E2, ARFP/F protein, p7) and nonstructural (NS2-3 autoprotease, NS3-4A, NS4B, NS5A, NS5B) proteins. Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors worldwide, with increasing incidence. It is estimated that approximately 300-400 thousands of people in the IRAN and 4 million in the United States are persistently infected. It is important for tumor control to identify the factors that predispose patients to death. A large number of molecular factors have been shown to associate with the invasiveness of HCC, and have potential prognostic significance.

Keywords

Hepatitis C Virus (HCV)

Hepatocellular Carcinoma

Genomic and Proteomics

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