Full Text
Full text is available in PDF
Official Journal of Research Center for Gastroenterology and Liver Diseases
e-ISSN 1735-3408
p-ISSN 1735-143X
Molecular Aspects of Hepatocellular Carcinoma Caused by Hepatitis C Virus
Authors
1Research Center of Molecular biology, Baqiyatallah University of Medical Sciences, [email protected], Tehran, IR.Iran
2Liver and Gastroentestinal Research Center, Baqiyatallah University of Medical Sciences and Tehran Hepatitis Center, Tehran, IR.Iran
*Corresponding Author: Research Center of Molecular biology, Baqiyatallah University of Medical Sciences, [email protected], Tehran, IR.Iran. Tel: +98 21 88039883. Fax: +98 21 88057023. Email: [email protected]
Published online:Dec 31, 2006
Article type:Review Article
Received:May 12, 2006
Accepted:May 25, 2006
How to Cite:Karami A, Alavian S, Najafi A, Hosseini M. Molecular Aspects of Hepatocellular Carcinoma Caused by Hepatitis C Virus. Hepat Mon. 2006;6(2):. doi:
Abstract
The hepatitis C virus (HCV) is a small, enveloped, single-stranded positive sense RNA virus with a diameter of about 50 nm belonging to the Hepacivirus genus of the family Flaviviridae. The HCV genome is translated to produce a single protein of around 3011 amino acids. This "polyprotein" is then proteolytically processed by viral and cellular proteases to produce structural (core protein, envelope glycoproteins E1 and E2, ARFP/F protein, p7) and nonstructural (NS2-3 autoprotease, NS3-4A, NS4B, NS5A, NS5B) proteins. Hepatocellular carcinoma (HCC) is one of the most frequent malignant tumors worldwide, with increasing incidence. It is estimated that approximately 300-400 thousands of people in the IRAN and 4 million in the United States are persistently infected. It is important for tumor control to identify the factors that predispose patients to death. A large number of molecular factors have been shown to associate with the invasiveness of HCC, and have potential prognostic significance.
Highlights
Copyright
© 2006, Author(s). This open-access article is available under the Creative Commons Attribution 4.0 (CC BY 4.0) International License (https://creativecommons.org/licenses/by/4.0/), which allows for unrestricted use, distribution, and reproduction in any medium, provided that the original work is properly cited.
Similar Articles
20
Oct
2012
Effects of Antiviral Therapy on the Recurrence of Hepatocellular Carcinoma After Curative Resection or Liver Transplantation
Yan Du,
Tong Su,
Yibo Ding,
Guangwen Cao
Du Y, Su T, Ding Y, Cao G. Effects of Antiviral Therapy on the Recurrence of Hepatocellular Carcinoma After Curative Resection or Liver Transplantation. Hepat Mon. 2012;12(10):6031. doi: https://doi.org/10.5812/hepatmon.6031
25
Oct
2012
Hepatitis B- and Hepatitis C-Related Hepatocellular Carcinomas in the United States: Similarities and Differences
Jennifer Ng,
Jennifer Wu
Ng J, Wu J. Hepatitis B- and Hepatitis C-Related Hepatocellular Carcinomas in the United States: Similarities and Differences. Hepat Mon. 2012;12(10):7635. doi: https://doi.org/10.5812/hepatmon.7635
30
Apr
2011
The differences in gene expression profile induced by genotype 1b hepatitis C virus core isolated from liver tumor and adjacent non-tumoral tissue
Xue-bing Yan,
Zhi Chen,
Christian Brechot
Yan X, Chen Z, Brechot C. The differences in gene expression profile induced by genotype 1b hepatitis C virus core isolated from liver tumor and adjacent non-tumoral tissue. Hepat Mon. 2011;11(4):. doi:
3
Jul
2013
Differentially Expressed Proteins in Chronic Active Hepatitis, Cirrhosis, and HCC Related to HCV Infection in Comparison With HBV Infection: A proteomics study
Jamal Sarvari,
Zahra Mojtahedi,
Seyed Ali Reza Taghavi,
Yasuhiro Kuramitsu,
Mahmoud Shamsi Shahrabadi,
Abbas Ghaderi
,et al.Sarvari J, Mojtahedi Z, Taghavi SAR, Kuramitsu Y, Shamsi Shahrabadi M, et al. Differentially Expressed Proteins in Chronic Active Hepatitis, Cirrhosis, and HCC Related to HCV Infection in Comparison With HBV Infection: A proteomics study. Hepat Mon. 2013;13(7):e8351. doi: https://doi.org/10.5812/hepatmon.8351
31
Jan
2012
Clinical Features of Hepatitis C Virus Carriers With Persistently normal Alanine Aminotransferase Levels
Hirofumi Uto,
Hirofumi Uto,
Seiich Mawatari,
Seiich Mawatari,
Kotaro Kumagai,
Kotaro Kumagai
,et al.Uto H, Uto H, Mawatari S, Mawatari S, Kumagai K, et al. Clinical Features of Hepatitis C Virus Carriers With Persistently normal Alanine Aminotransferase Levels. Hepat Mon. 2012;12(2):. doi: https://doi.org/10.5812/hepatmon.829
Cited by
- Scopus by DOI: 0
Last Update: 3 days ago
- Scopus by Title: 0
Last Update: 3 days ago
- Scopus by Title (Ref): 0
Last Update: 3 days ago
- CrossRef: 0
Last Update: 6 days ago
Comments
Number of Comments:0