https://doi.org/10.5812/ijcm.112003

Metanephric Adenoma: A Case Report of a Rare Benign Renal Tumor

authors:

avatar Farzad Allameh ORCID 1 , avatar Mahsa Ahadi ORCID 2 , avatar Saba Faraji ORCID 3 , avatar Seyyed Ali Hojjati ORCID 4 , *

Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran
Department of Urology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
International Journal of Cancer Management: Vol.14, issue 7; e112003
published online: July 20, 2021
article type: Case Report
received: December 8, 2020
revised: February 6, 2021
accepted: February 8, 2021

How To Cite Allameh F, Ahadi M, Faraji S, Hojjati S A. Metanephric Adenoma: A Case Report of a Rare Benign Renal Tumor. Int J Cancer Manag. 2021;14(7):e112003. https://doi.org/10.5812/ijcm.112003.

Abstract

Introduction:

Metanephric adenoma (MA) is a rare benign kidney tumor with an excellent prognosis, which is usually diagnosed incidentally with no symptoms. The mean age of patients with MA is about 41 years, ranging from 5 months to 83 years in previous studies.

Case Presentation:

In this study, we present the case of a 29-year-old woman with a diagnosis of MA after nephrectomy. The ultrasound study showed a hyperechoic mass. The intravenous (IV) contrast-enhanced abdominopelvic computed tomography (CT) scan showed a hypodense mass. Based on the results of pathological features and immunohistochemistry (IHC) (positive vimentin, WT1, and PAX8), the diagnosis of MA was established.

Conclusions:

The diagnosis of MA is commonly based on pathological findings. Therefore, if MA is suspected, renal biopsy, partial nephrectomy, or follow-up of the patient can be used. However, further studies are needed to differentiate MA from papillary renal cell carcinoma and nephroblastoma before taking aggressive measures.

1. Introduction

Metanephric adenoma (MA) is a rare benign kidney tumor with an excellent prognosis (1). The most common part of the kidney involved in various benign or malignant tumors is the tubular epithelium (2). MA originates from epithelial cells, and because of its commonly unspecific clinical and radiological characteristics, it can be difficult to distinguish it from malignant neoplasms preoperatively (3, 4). The definitive diagnosis of MA depends on the postoperative pathological findings (5). MA is derived from the residual renal organization during embryonic development (4). It is also considered to arise from different forms of maturation-arrested embryonic rests, persistent blastoma, or maturing nephroblastoma (6).

According to previous studies, about 0.2% of renal tumors are MA (7). The mean age of patients with MA is about 41 years, ranging from 5 months to 83 years, as reported in previous studies. The female-to-male incidence ratio is about 2: 1. The mean size of MA is about 5.5 cm with a range of 0.3 to 15 cm (8). MA is commonly diagnosed incidentally with no symptoms. The presenting symptoms of MA include hematuria, pyrexia, flank pain, abdominal mass, and polycythemia (9). In this study, we aimed at describing the case of a 29-year-old woman with a diagnosis of MA after nephrectomy.

2. Case Presentation

The patient was a 29-year-old woman with a history of diabetes and hypothyroidism, who was referred to the hospital emergency department due to right lower quadrant (RLQ) pain. She did not have any urinary symptoms, such as hematuria. Possible gynecological factors were ruled out by an obstetrician/gynecologist. Due to the suspicion of appendicitis, she was monitored by a general surgeon. She underwent routine laboratory and ultrasound examinations by the general surgery team. The renal ultrasound revealed a cyst with an internal echogenic content, high internal echogenic foci, and a thick wall, suggesting malignancy. Also, the ultrasound study was not in favor of appendicitis. The hospital urologist visited the patient and requested a computed tomography (CT) scan of the abdomen and pelvis, with and without intravenous (IV) contrast injection. The CT scan with contrast indicated a lesion with dimensions of 40 × 37 mm. A craniocaudal lesion (36 mm) was also seen in the lower pole of the right kidney (Figure 1).

The abdominopelvic CT scan with IV contrast
The abdominopelvic CT scan with IV contrast
Figure 1.

The abdominopelvic CT scan with IV contrast

In images without contrast injection, the mass was measured at 40 Hounsfield Units (HU), and in images with contrast injection in the portal phase, it was measured at 70 HU. Due to the enhancement changes of more than 20 HU, enhancement was proposed for the lesion. According to the ultrasound, the lesion was homogeneous and contained echogenic areas. The wall thickness in the lateral section was about 3 mm (minimally thick). Overall, the findings suggested a hypovascular tumor, while no evidence of lymphadenopathy was seen. The delayed phase of IV contrast-enhanced CT scan was also performed. After 2 days of observation, appendicitis was ruled out. Regarding the laboratory tests, routine blood tests were normal, with a hemoglobin level of 12.8 g/L, a creatinine level of 1.1 mg/dL, an erythrocyte sedimentation rate (ESR) of 13 mm/h, and a glomerular filtration rate (GFR) of 83 mL/min.

A spiral chest CT scan was carried out for the patient, which indicated normal results. The patient was considered eligible for partial nephrectomy by the urologist. However, due to extensive blood supply to the lower pole of the right kidney during surgery, she underwent a radical right nephrectomy. The nephrectomy specimen revealed a round, well-defined, tan, solid, encapsulated mass, measuring 4.5 × 4 × 3 cm in the lower pole. It did not communicate with the collective system, and no enlarged lymph nodes were detected. The microscopic sections showed a basophilic neoplasm, composed of tightly packed ducts with a scant papillary architecture. The tumor cells had a scant cytoplasm and small nuclei. Mitosis was low, and scant psammomatous calcification was seen (Figure 2). Immunohistochemically, the specimen was positive for Wilm’s Tumor 1 (WT1), vimentin, and Paired-box gene 8 (PAX8), which strongly suggested MA (Figure 3). The patient recovered completely after the surgery.

The H&E staining indicates a blue cellular tumor, composed of tightly packed, long branching, angulated ducts in a papillary architecture. Psammomatous calcification is also seen.
The H&E staining indicates a blue cellular tumor, composed of tightly packed, long branching, angulated ducts in a papillary architecture. Psammomatous calcification is also seen.
Figure 2.

The H&E staining indicates a blue cellular tumor, composed of tightly packed, long branching, angulated ducts in a papillary architecture. Psammomatous calcification is also seen.

The positive results of IHC for WT1 and vimentin
The positive results of IHC for WT1 and vimentin
Figure 3.

The positive results of IHC for WT1 and vimentin

Written and signed informed consent was taken from the patient for publishing the manuscript. This study was approved by the Ethics Committee of Shahid Beheshti University of Medical Sciences. The patient's private information remained confidential with the researchers.

3. Discussion

MA was first described by Brisigotti et al. in 1992. It has been recently classified in the group of metanephric tumors, which also include metanephric adenofibroma and stromal metanephric tumors (10). Any type of kidney tumor can be asymptomatic (11). MA is commonly asymptomatic and is found incidentally (5). Inflammatory and infectious processes, such as pyelonephritis, can delay the diagnosis of kidney tumors (12). The patient did not have any signs or symptoms of pyelonephritis. Considering the benign nature of the mass, the best surgical option for the patient was partial nephrectomy. However, since it was not possible to differentiate it from malignant masses before surgery, based on pathological examinations, radical nephrectomy is also available for the patients (13-15).

Although pathology can usually lead to a definitive diagnosis of MA, there is still an overlap between MA and papillary renal cell carcinoma (PRCC) (16). Most MA cases are well-defined, ovoid, cystic-solid, or solid renal masses with calcifications of various sizes, as well as necrotic and hemorrhagic areas (17). The ultrasound imaging results can be different for MA (hyperechoic, isoechoic, or hypoechoic) (17). In our case, the ultrasound imaging showed a hyperechoic mass. On CT scan, MA is usually well-defined with no distinct attenuation patterns; it is mostly spontaneous and slightly hyperdense compared to the normal renal parenchyma. MA may present as an isodense or hyperdense mass in CT scans with central necrosis (17). In our case, the CT scan showed a hypodense mass.

MA has some differential diagnoses, such as Wilms tumor and atypical angiomyolipoma. MA and PRCC both have homogenous densities and mild enhancements; therefore, it is difficult to distinguish between these two conditions (17). The tumor size can vary from 3 mm to 15 cm (5). The tumor is usually solid, although it can be cystic, as well (18). The tumor surface, cut by the pathologist, is usually tan to grey or yellow with hemorrhagic foci in about 20% of mass calcifications. These tumors usually lack a fibrous capsule (5). In our case, the specimen revealed a round, well-defined, tan, solid, encapsulated mass.

Microscopically, MA is composed of tightly packed, uniform, small epithelial cells with small regular nuclei, basophilic cytoplasm, a high nuclei-to-cytoplasm ratio, and no mitotic figures. The cells may be arranged in tubular or papillary architectural patterns, and glomeruloid bodies may be found. The stroma ranges from an inconspicuous to a paucicellular edematous appearance. Psammomatous calcifications are common (19). In our case, the microscopic sections showed a blue cellular tumor, composed of tightly packed, long-branching, angulated ducts with papillary architecture. Tumor cells have scant cytoplasm and small nuclei without nucleoli. Stroma is scanty and edematous in some areas; psammomatous calcification is seen, as well.

Immunohistochemical staining is also useful for diagnosing MA. It is especially useful when it is difficult to differentiate MA from PRCC. PRCC is usually positive for alpha-methylacyl-CoA racemase (AMACR) and cytokeratin 7 (CK7), whereas MA is usually positive for WT1, vimentin, and complement receptor 57 (CD57). The combination of CK7–, AMACR–, WT1+, and CD57+ is characteristic of MA (20). In our case, IHC was carried out for vimentin and WT1, which indicated positive results; however, we did not have access to AMACR or CK7.

MA has some differential diagnoses, such as PRCC and nephroblastoma. We can differentiate these tumors according to the results of IHC (Table 1) (20). CT scan and other imaging findings do not make a clear distinction between MA and its differential diagnoses. A biopsy can be used to differentiate between these tumors if there is any suspicion (17). MA is a rare kidney tumor that cannot be differentiated from PRCC solely based on clinical and radiological features, and its diagnosis is usually based on pathological findings. Therefore, further studies are needed to differentiate MA from PRCC and nephroblastoma before taking aggressive measures.

Table 1.

Differential Diagnosis of MA and Comparison of the Results of IHC

Renal TumorThe Results of IHC
MA WT1 (+), CD57 (+), BRAF (+), PAX8 (+), Cadherin 17 (+), AMACR (-), CK7 (-), CD56 (-), and EMA (-)
PRCCVimentin (+), PAX8 (+), CK7 (+), AMACR (+), WT1(-), CD57 (-), and BRAF (-)
NephroblastomaPAX8 (+), WT1 (+), Vimentin (-), CD57 (-), and BRAF (-)

Abbreviations: IHC, immunohistochemistry; MA, metanephric adenoma; PRCC, papillary renal cell carcinoma; WT1, Wilm’s tumor 1; BRAF, v-raf murine sarcoma viral oncogene homolog B1; CD57, complement receptor 57; PAX8, paired-box gene 8 (PAX8); AMACR, alpha-methylacyl-CoA racemase; CK7, cytokeratin 7; EMA, epithelial membrane antigen.

References

  • 1.

    Le Nue R, Marcellin L, Ripepi M, Henry C, Kretz JM, Geiss S. Conservative treatment of metanephric adenoma. A case report and review of the literature. J Pediatr Urol. 2011;7(4):399-403. [PubMed ID: 21220212]. https://doi.org/10.1016/j.jpurol.2010.09.010.

  • 2.

    Allameh F, Fallah Karkan M, Rakhshan A. Renal rhabdomyosarcoma in a young woman with gross hematuria: A case report. Int J Cancer Manag. 2017;10(9). https://doi.org/10.5812/ijcm.10649.

  • 3.

    Lai Y, Chen D, Xu X, Yu Z, Ni L, Yang S, et al. Metanephric adenoma: A report of two cases and review of the literature. Mol Clin Oncol. 2013;1(6):1087-9. [PubMed ID: 24649298]. [PubMed Central ID: PMC3915692]. https://doi.org/10.3892/mco.2013.184.

  • 4.

    Fan H, Shao QQ, Li HZ, Xiao Y, Zhang YS. The clinical characteristics of metanephric adenoma: A case report and literature review. Medicine (Baltimore). 2016;95(21). e3486. [PubMed ID: 27227914]. [PubMed Central ID: PMC4902338]. https://doi.org/10.1097/MD.0000000000003486.

  • 5.

    Zhang L, Gao X, Li R, Li K, Liu B, Li J, et al. Experience of diagnosis and management of metanephric adenoma: Retrospectively analysis of 10 cases and a literature review. Transl Androl Urol. 2020;9(4):1661-9. [PubMed ID: 32944527]. [PubMed Central ID: PMC7475680]. https://doi.org/10.21037/tau-19-912.

  • 6.

    Sarlos DP, Banyai D, Peterfi L, Szanto A, Kovacs G. Embryonal origin of metanephric adenoma and its differential diagnosis. Anticancer Res. 2018;38(12):6663-7. [PubMed ID: 30504374]. https://doi.org/10.21873/anticanres.13033.

  • 7.

    Amin MB, Amin MB, Tamboli P, Javidan J, Stricker H, de-Peralta Venturina M, et al. Prognostic impact of histologic subtyping of adult renal epithelial neoplasms: An experience of 405 cases. Am J Surg Pathol. 2002;26(3):281-91. [PubMed ID: 11859199]. https://doi.org/10.1097/00000478-200203000-00001.

  • 8.

    Davis CJJ, Barton JH, Sesterhenn IA, Mostofi FK. Metanephric adenoma. Clinicopathological study of fifty patients. Am J Surg Pathol. 1995;19(10):1101-14. [PubMed ID: 7573669]. https://doi.org/10.1097/00000478-199510000-00001.

  • 9.

    Wang P, Tian Y, Xiao Y, Zhang Y, Sun FA, Tang K. A metanephric adenoma of the kidney associated with polycythemia: A case report. Oncol Lett. 2016;11(1):352-4. [PubMed ID: 26870216]. [PubMed Central ID: PMC4727092]. https://doi.org/10.3892/ol.2015.3868.

  • 10.

    Brisigotti M, Cozzutto C, Fabbretti G, Sergi C, Callea F. Metanephric adenoma. Histol Histopathol. 1992;7(4):689-92. [PubMed ID: 1333853].

  • 11.

    Allameh F, Najafi S, Fallah Karkan M, Haghighatkhah H, Nekuie S. Chromophobe renal cell carcinoma presented with wunderlich syndrome. Int J Cancer Manag. 2017;10(11). https://doi.org/10.5812/ijcm.8057.

  • 12.

    Song SK, Song JS, Hwang HP, Lee S. Acute pyelonephritis including an overlooked renal cell carcinoma. Clin Nephrol Case Stud. 2013;1:7-9. [PubMed ID: 29043118]. [PubMed Central ID: PMC5437987]. https://doi.org/10.5414/CNCS107906.

  • 13.

    Xu B, Zhang Q, Jin J. A case of central metanephric adenoma successfully treated with laparoscopic nephron-sparing surgery. Urology. 2012;80(2):e19-20. [PubMed ID: 22705110]. https://doi.org/10.1016/j.urology.2012.04.035.

  • 14.

    Kumar S, Mandal AK, Acharya NR, Kakkad N, Singh SK. Laparoscopic nephron-sparing surgery for metanephric adenoma. Surg Laparosc Endosc Percutan Tech. 2007;17(6):573-5. [PubMed ID: 18097330]. https://doi.org/10.1097/SLE.0b013e3181568389.

  • 15.

    Kosugi M, Nagata H, Nakashima J, Murai M, Hata J. [A case of metanephric adenoma treated with partial nephrectomy]. Nihon Hinyokika Gakkai Zasshi. 2000;91(4):489-92. Japanese. [PubMed ID: 10826249]. https://doi.org/10.5980/jpnjurol1989.91.489.

  • 16.

    Mantoan Padilha M, Billis A, Allende D, Zhou M, Magi-Galluzzi C. Metanephric adenoma and solid variant of papillary renal cell carcinoma: Common and distinctive features. Histopathology. 2013;62(6):941-53. [PubMed ID: 23551615]. https://doi.org/10.1111/his.12106.

  • 17.

    Hu YC, Wu L, Yan LF, Zhang W, Cui GB. The imaging features of metanephric adenoma: A case report and review of literature. Onco Targets Ther. 2015;8:445-9. [PubMed ID: 25709478]. [PubMed Central ID: PMC4335625]. https://doi.org/10.2147/OTT.S68819.

  • 18.

    Patankar T, Punekar S, Madiwale C, Prasad S, Hanchate V. Metanephric adenoma in a solitary kidney. Br J Radiol. 1999;72(853):80-1. [PubMed ID: 10341694]. https://doi.org/10.1259/bjr.72.853.10341694.

  • 19.

    Granter SR, Fletcher JA, Renshaw AA. Cytologic and cytogenetic analysis of metanephric adenoma of the kidney: A report of two cases. Am J Clin Pathol. 1997;108(5):544-9. [PubMed ID: 9353093]. https://doi.org/10.1093/ajcp/108.5.544.

  • 20.

    Kinney SN, Eble JN, Hes O, Williamson SR, Grignon DJ, Wang M, et al. Metanephric adenoma: The utility of immunohistochemical and cytogenetic analyses in differential diagnosis, including solid variant papillary renal cell carcinoma and epithelial-predominant nephroblastoma. Mod Pathol. 2015;28(9):1236-48. [PubMed ID: 26248896]. https://doi.org/10.1038/modpathol.2015.81.